CACNA1C and CACNB3

Number of citations of the paper that reports this interaction (PubMedID 15170217)
125

Data Source:
HPRD (in vitro)

		CACNA1C	CACNB3
Description		calcium voltage-gated channel subunit alpha1 C	calcium voltage-gated channel auxiliary subunit beta 3
Image			No pdb structure
GO Annotations	Cellular Component	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Cell Junction Dendrite Perikaryon Postsynaptic Density Membrane L-type Voltage-gated Calcium Channel Complex	Cell Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane Synapse L-type Voltage-gated Calcium Channel Complex
	Molecular Function	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Metal Ion Binding Alpha-actinin Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential	Voltage-gated Calcium Channel Activity Calcium Channel Regulator Activity Protein Binding High Voltage-gated Calcium Channel Activity Protein Kinase Binding
	Biological Process	Immune System Development Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Viral Process Embryonic Forelimb Morphogenesis Calcium-mediated Signaling Using Extracellular Calcium Source Camera-type Eye Development Positive Regulation Of Adenylate Cyclase Activity Regulation Of Insulin Secretion Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Calcium Ion Import Calcium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Depolarization During AV Node Cell Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential	Calcium Ion Transport Chemical Synaptic Transmission Neuromuscular Junction Development T Cell Receptor Signaling Pathway Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Membrane Depolarization Calcium Ion Transport Into Cytosol Cardiac Conduction Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Protein Localization To Plasma Membrane Positive Regulation Of Protein Targeting To Membrane Cellular Response To Oxygen-glucose Deprivation Regulation Of Membrane Repolarization During Action Potential Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Membrane Hyperpolarization Negative Regulation Of Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase	Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase
Drugs		Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Spironolactone Cinnarizine Nicardipine Magnesium Sulfate Verapamil Ethanol Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine Trimebutine Manidipine	Nimodipine Spironolactone Verapamil Mibefradil Dronedarone Trimebutine Manidipine
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS) Brugada syndrome (BRS)
GWAS		Acoustic startle blink response ( 25387708) Adventurousness ( 30643258) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aortic root size ( 28394258) Atypical femoral fracture in phosphonate treatment ( 31006051) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365 31043756 28072414 20351715) Bipolar disorder or major depressive disorder ( 20351715) Bipolar I disorder ( 31043756) Broad depression or bipolar disorder ( 30626913) Broad depression or schizophrenia ( 30626913) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 30224653) Exploratory eye movement dysfunction in schizophrenia (cognitive search score) ( 26242244) Fractional exhaled nitric oxide (childhood) ( 24315451) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Perceived intensity of aspartame ( 31005972) Post bronchodilator FEV1/FVC ratio ( 26634245) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Red blood cell count ( 29403010 27863252) Red blood cell traits ( 23222517) Response to olanzapine in schizophrenia ( 29503163) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872) Schizophrenia or bipolar disorder ( 24280982) Sensorimotor dexterity ( 31596458) Short-term memory (digit-span task) ( 30741946) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Interacting Genes		11 interacting genes: CABP1 CACNB3 COPS5 GNB1 HDAC4 PCBD1 PPM1A PRKACA RIMS1 RYR2 SRI	4 interacting genes: CACNA1B CACNA1C FASLG SYT1
Entrez ID		775	784
HPRD ID		00246	11879
Ensembl ID		ENSG00000151067	ENSG00000167535
Uniprot IDs		A0A0A0MR67 A0A0A0MSA1 F5H522 Q13936 Q59GU3 Q5V9X9	P54284
PDB IDs		1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ 5V2P 5V2Q 6C0A 6DAD 6DAE 6DAF
Enriched GO Terms of Interacting Partners?
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