CACNA1A and PUF60

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CACNA1A	PUF60
Description		calcium voltage-gated channel subunit alpha1 A	poly(U) binding splicing factor 60
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Integral Component Of Membrane Cell Projection Neuronal Cell Body Synapse	Nucleoplasm Cell Junction
	Molecular Function	Amyloid-beta Binding Voltage-gated Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Syntaxin Binding Metal Ion Binding	DNA Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Calcium Ion Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Chemical Synaptic Transmission Cell Death Regulation Of Ion Transmembrane Transport Regulation Of Insulin Secretion Modulation Of Chemical Synaptic Transmission Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Response To Amyloid-beta Cellular Response To Amyloid-beta	MRNA Splicing, Via Spliceosome Apoptotic Process
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion	mRNA Splicing - Major Pathway
Drugs		Pregabalin Spironolactone Verapamil Loperamide Bepridil
Diseases		Episodic ataxias Familial or sporadic hemiplegic migraine Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Exfoliation syndrome ( 25706626) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		92 interacting genes: ABCA2 ABI1 ACTN1 ADGRL1 AGRN ALDOA AMIGO2 AP2M1 ARHGAP22 BTG3 C1QTNF1 CABP1 CACNB1 CACNB4 CALM2 CALM3 CKAP5 CRIM1 CRMP1 CSNK2B CYSRT1 DNAJB5 EFEMP1 EFEMP2 EHMT2 EIF3A FBLN1 GET3 GNB1 GOLGA6L5P GRN HECW1 HHATL HIVEP1 HSPG2 IP6K1 JAG2 KALRN KHDRBS3 KIAA1191 LAMB1 LLGL1 LRP1 LTBP1 LTBP3 LTBP4 MANBAL MATK MATN2 MEGF6 MEGF8 MIA3 MOAP1 NDUFB8 NELFCD NELL1 NELL2 NOTCH1 NOXA1 OLIG1 PCSK5 PCSK6 PMM1 PPIG PPM1A PPP1R12C PTGDS PUF60 RBM12B RIMBP2 RPL31 RPS17 SCP2 SPRY1 SRRM4 SRSF1 SUMF2 SYT1 TAF15 TELO2 TSC22D1 TSPAN7 TSPOAP1 TUBB2B UQCRC2 VARS1 VPS52 VWF WBP1 YLPM1 ZCCHC17 ZNF233	34 interacting genes: ARL8A BORCS5 CACNA1A CCNC CD101 CHD3 CPEB2 ERG FBXO7 FHL2 FUBP1 H1-2 ID3 IQCN KHDC4 LARP7 MED28 PCBP1 PPP1R16A PTBP2 QRICH1 RAD23B RAP1GDS1 SAP30BP SDCBP SIAH1 SNRPF SRSF11 U2AF2 UBE2I UPF2 VIM YWHAG ZG16
Entrez ID		773	22827
HPRD ID		03004	18051
Ensembl ID		ENSG00000141837	ENSG00000179950
Uniprot IDs		A0A087WW63 B5TYJ1 O00555 Q9NS89	Q9UHX1
PDB IDs		3BXK	2DNY 2KXF 2KXH 2QFJ 3DXB 3UE2 3US5 3UWT 5KVY 5KW1 5KW6 5KWQ
Enriched GO Terms of Interacting Partners?
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