TRIM26 and USP5

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		TRIM26	USP5
Description		tripartite motif containing 26	ubiquitin specific peptidase 5
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Nucleus Cytosol	Lysosome Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Zinc Ion Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding
	Biological Process	Innate Immune Response Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Viral Release From Host Cell	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Deubiquitination
Pathways		Interferon gamma signaling	Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) General cognitive ability ( 29844566) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Neuroticism ( 29255261) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 21926974 22883433 30285260) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		20 interacting genes: INCA1 IRF3 LMNA MAGEA6 MNAT1 OTUB2 PHF7 RABEP1 RNF10 RNF126 SUMO2 THAP1 TLE5 TRIM41 UBE2D1 UBE2D2 UBE2D3 USP36 USP39 USP5	23 interacting genes: APP CACNA1H DAZAP2 DVL2 PJA1 PLA2G2A RFFL RNF11 SMURF1 STK33 TADA3 TMEM239 TRAF6 TRIM26 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIML1 UBE2S UBTD2 USP28
Entrez ID		7726	8078
HPRD ID		02901	03265
Ensembl ID		ENSG00000234127	ENSG00000111667
Uniprot IDs		A0A024RCP3 Q12899	A0A140VJZ1 P45974
PDB IDs			2DAG 2DAK 2G43 2G45 3IHP 6DXH 6DXT 6NFT 6P9G
Enriched GO Terms of Interacting Partners?
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