ZNF135 and RAP1B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		ZNF135	RAP1B
Description		zinc finger protein 135	RAP1B, member of RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Intracellular Lipid Droplet Cytosol Plasma Membrane Cell-cell Junction Membrane Azurophil Granule Membrane Membrane Raft Extracellular Exosome
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Metal Ion Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Protein-containing Complex Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cytoskeleton Organization Regulation Of Cell Morphogenesis	Cell Proliferation Response To Carbohydrate Microvillus Assembly Rap Protein Signal Transduction Positive Regulation Of Integrin Activation Cellular Response To Drug Interleukin-12-mediated Signaling Pathway Neutrophil Degranulation Negative Regulation Of Calcium Ion-dependent Exocytosis Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Cellular Response To Gonadotropin-releasing Hormone Regulation Of Cell Junction Assembly Regulation Of Establishment Of Cell Polarity Negative Regulation Of Synaptic Vesicle Exocytosis
Pathways		Generic Transcription Pathway	Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Signaling downstream of RAS mutants
Drugs
Diseases
GWAS			White blood cell count ( 20139978)
Interacting Genes		6 interacting genes: ANXA7 CDKN1A GADD45A GSK3B RAP1B RCC1	29 interacting genes: A2M ALAS1 APLP1 APP CCT7 CHGB CSAD DDAH2 FAF1 HRAS KMT2B LRIF1 PDHB PKM PRKACA RAB7B RALGDS RAPGEF1 RASSF5 RGL2 RGS2 RPTOR SDF4 SMURF2 TLE1 TP53 UNC119 ZDHHC17 ZNF135
Entrez ID		7694	5908
HPRD ID		07242	01546
Ensembl ID		ENSG00000176293	ENSG00000127314
Uniprot IDs		B4DLZ7 P52742 Q8N9M3	A0A024RB87 B7ZAY2 P61224
PDB IDs			3BRW 3CF6 4DXA 4HDO 4HDQ 4M8N 4MGI 4MGK 4MGY 4MGZ 4MH0 5KHO 6AXF 6BA6
Enriched GO Terms of Interacting Partners?
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