ZIC3 and POFUT1

		ZIC3	POFUT1
Description		Zic family member 3	protein O-fucosyltransferase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Fucosyltransferase Activity Peptide-O-fucosyltransferase Activity
	Biological Process	Heart Looping Regulation Of Transcription By RNA Polymerase II Determination Of Left/right Symmetry Central Nervous System Development Anterior/posterior Pattern Specification Cell Differentiation Lung Development Somatic Stem Cell Population Maintenance Determination Of Pancreatic Left/right Asymmetry Determination Of Left/right Asymmetry In Nervous System Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Determination Of Digestive Tract Left/right Asymmetry Determination Of Liver Left/right Asymmetry	Angiogenesis Somitogenesis Fucose Metabolic Process Regulation Of Transcription, DNA-templated Protein O-linked Glycosylation Notch Signaling Pathway Nervous System Development Heart Development Regulation Of Notch Signaling Pathway O-glycan Processing Protein O-linked Fucosylation
Pathways		POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells	Pre-NOTCH Processing in the Endoplasmic Reticulum
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS			Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease ( 28166215) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Inflammatory bowel disease ( 28067908)
Interacting Genes		6 interacting genes: CTNNB1 GLI3 POFUT1 SRF TP53 TWIST1	13 interacting genes: AKT2 DEFB115 DEFB116 DLL1 DUSP15 ERGIC3 ID1 JAG1 NAP1L2 NOTCH1 PTPRA USH2A ZIC3
Entrez ID		7547	23509
HPRD ID		02225	06319
Ensembl ID		ENSG00000156925	ENSG00000101346
Uniprot IDs		O60481	Q9H488
PDB IDs		2EJ4 2RPC	5UX6 5UXH
Enriched GO Terms of Interacting Partners?
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