XRCC5 and HSF1

Number of citations of the paper that reports this interaction (PubMedID 9325337)
12

Data Source:
HPRD (in vitro)

		XRCC5	HSF1
Description		X-ray repair cross complementing 5	heat shock transcription factor 1
Image
GO Annotations	Cellular Component	Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Extracellular Region Nucleus Nucleoplasm Nucleolus Cytosol Plasma Membrane Membrane Protein-containing Complex Protein-DNA Complex Secretory Granule Lumen Ku70:Ku80 Complex Nonhomologous End Joining Complex Site Of DNA Damage Ribonucleoprotein Complex	Kinetochore Condensed Chromosome Kinetochore Nuclear Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol PML Body Pronucleus Perinuclear Region Of Cytoplasm Nuclear Stress Granule Mitotic Spindle Pole Chaperone Complex Ribonucleoprotein Complex
	Molecular Function	DNA Binding DNA Helicase Activity Damaged DNA Binding Double-stranded DNA Binding Double-stranded Telomeric DNA Binding RNA Binding Protein Binding ATP Binding Protein C-terminus Binding Enzyme Activator Activity Ubiquitin Protein Ligase Binding Telomeric DNA Binding Transcription Regulatory Region DNA Binding Protein-containing Complex Binding DNA End Binding 5'-deoxyribose-5-phosphate Lyase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Heat Shock Protein Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein Self-association Protein Heterodimerization Activity Hsp90 Protein Binding Translation Elongation Factor Binding STAT Family Protein Binding Sequence-specific Single Stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Telomere Maintenance Activation Of Innate Immune Response Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Brain Development Cell Proliferation Regulation Of Telomere Maintenance Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Response To Drug Positive Regulation Of Catalytic Activity Neutrophil Degranulation Innate Immune Response Positive Regulation Of Protein Kinase Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of Telomerase Activity Hematopoietic Stem Cell Differentiation Protein Localization To Chromosome, Telomeric Region Cellular Response To Fatty Acid Cellular Hyperosmotic Salinity Response Cellular Response To Gamma Radiation Cellular Response To X-ray Establishment Of Integrated Proviral Latency Negative Regulation Of T-circle Formation Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Embryonic Placenta Development DNA Repair MRNA Processing Defense Response Female Meiotic Nuclear Division Spermatogenesis Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation MRNA Transcription Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Response To Activity Viral Process Negative Regulation Of Protein Complex Assembly Negative Regulation Of Tumor Necrosis Factor Production Response To Testosterone Cellular Response To Heat Cellular Response To Unfolded Protein Cellular Protein-containing Complex Assembly Cellular Response To Potassium Ion Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Embryonic Process Involved In Female Pregnancy Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Heat Stress Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Estradiol Stimulus Cellular Response To Gamma Radiation Cellular Response To Diamide Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Inclusion Body Assembly Positive Regulation Of Cold-induced Thermogenesis Regulation Of Cellular Response To Heat Positive Regulation Of MRNA Polyadenylation Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic DNA Fragmentation Cellular Response To Sodium Arsenite Cellular Response To Angiotensin Positive Regulation Of Microtubule Binding Cellular Response To Nitroglycerin Cellular Response To L-glutamine Response To Hypobaric Hypoxia Response To Psychosocial Stress Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation	Regulation of HSF1-mediated heat shock response HSF1 activation Attenuation phase HSF1-dependent transactivation Aggrephagy
Drugs
Diseases
GWAS			Dupuytren's disease ( 28886342)
Interacting Genes		54 interacting genes: APEX1 AR ATM ATR BAZ1A BRCA1 CD40 CDC16 CEBPA CHAF1A COIL CSNK2A1 ELF3 GZMA GZMB HSF1 HSPB1 LIG3 MSX2 NAA15 NBN NCOA6 NDRG1 ORC2 PARP1 PCNA PDX1 PGR POLA1 POLD1 POLE POLR2A PRKDC RBM14 RNF126 RUNX2 SGO1 SRPK2 SUMO2 SUPT4H1 SUPT5H TCF4 TERF2IP TERT TOP1 TOP2B TYK2 UBC UBE2I UCHL3 VAV1 WRN XRCC6 ZBTB7A	50 interacting genes: CAMK2A CDC20 CDK6 CEBPB CHST10 CREBBP CSNK2A1 DAXX DNAJB1 EEF1D ENO2 FILIP1 FKBP4 FKBP5 GSK3A GTF2A2 GTF2B HSBP1 HSF2 HSP90AA1 HSP90AB1 HSPA1A HSPA8 MAPK1 MAPK3 MAPK8 MAPK9 MAPKAPK2 NCOA6 PPID PRKDC PTGES3 RALBP1 REPS1 RNF20 SMARCA4 STAT1 STUB1 SUB1 SUMO1 SUMO3 SYMPK TAF1 TAF7 TAF9 TBP UBE2I XRCC5 XRCC6 YWHAE
Entrez ID		7520	3297
HPRD ID		08935	00778
Ensembl ID		ENSG00000079246	ENSG00000185122
Uniprot IDs		P13010	Q00613
PDB IDs		1JEQ 1JEY 1Q2Z 1RW2 3RZ9 5Y3R 6ERF 6ERG 6ERH	2LDU 5D5U 5D5V 5HDG 5HDN
Enriched GO Terms of Interacting Partners?
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