WT1 and KRTAP10-8

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		WT1	KRTAP10-8
Description		WT1 transcription factor	keratin associated protein 10-8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Cytosol Keratin Filament
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Hemi-methylated DNA-binding C2H2 Zinc Finger Domain Binding	Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of DNA Methylation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	Keratinization
Pathways			Keratinization
Drugs
Diseases		Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Birth weight ( 31043758) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		55 interacting genes: AREG CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 PAWR PAX2 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 U2AF2 UBE2I WTAP WTIP ZNF205	165 interacting genes: - ACY3 ADAMTSL3 ADAMTSL4 AEN ALDH3B1 ALPI AMMECR1 APOL6 ASPSCR1 ATG9A BEX2 BMP7 C11orf87 CARHSP1 CATSPER1 CCDC26 CCNJL CHIC2 CHRD CHRNG CLK4 CNNM3 COL8A1 CRCT1 CREB5 DAAM2 DCX DDX55 DDX6 DERL2 DHRS1 DHX57 DMRT3 DOCK2 EIF4E2 FAH FAM27E3 FAM74A4 FAM76B FBXW5 FOXB1 GFOD1 GLIDR GLP1R GLRX3 GLYAT GNAI2 GNE GOLGA8EP HHEX HOXA1 HPCAL1 HSD3B7 HSPD1 IGSF8 ITGB5 JOSD1 KLHL38 KRT20 KRT83 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE2D LCE3C LCE3E LCE4A LINC00656 LRCH4 LUZP4 LYVE1 MAPKBP1 MATN3 MEOX2 MLLT6 MOBP MTA1 MXI1 NAB2 NAXD NECTIN3 NOTCH2NLA NUFIP2 OTX1 P2RX7 PCED1A PCSK5 PDE9A PGLS PIGS PKD2 POM121L8P PRKAB2 PRPF31 PRR13 PTGER3 PTPMT1 PTPRH PVR QPRT R3HDM2 RANBP3 RPS28 RTN4RL1 SCNM1 SHFL SLC22A23 SLC23A1 SLC25A10 SLC6A20 SMCP SMOC1 SPACA9 SPATA3 SPRY1 SPRY2 STK16 SUSD6 TBC1D16 TBC1D23 THAP10 THAP7 TLE5 TMEM150A TNIP3 TNP2 TNS2 TRPV6 TXNDC5 TYMSOS TYRO3 UTP23 UXT VPS11 WIF1 WT1 WT1-AS YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF138 ZNF20 ZNF32 ZNF417 ZNF439 ZNF473 ZNF572 ZNF578 ZNF587 ZNF697 ZSCAN21
Entrez ID		7490	386681
HPRD ID		06163	11194
Ensembl ID		ENSG00000184937	ENSG00000187766
Uniprot IDs		P19544 Q6PI38	P60410
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW
Enriched GO Terms of Interacting Partners?
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