WNT6 and PORCN

Number of citations of the paper that reports this interaction (PubMedID 10866835)
33

Data Source:
HPRD (in vitro, in vivo)

		WNT6	PORCN
Description		Wnt family member 6	porcupine O-acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse
	Molecular Function	Frizzled Binding	Wnt-protein Binding Palmitoleoyltransferase Activity
	Biological Process	Branching Involved In Ureteric Bud Morphogenesis Axis Specification Positive Regulation Of Gene Expression Wnt Signaling Pathway Neuron Differentiation Odontogenesis Of Dentin-containing Tooth Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Epithelial-mesenchymal Cell Signaling Cornea Development In Camera-type Eye Positive Regulation Of Tooth Mineralization Cellular Response To Retinoic Acid Nephron Tubule Formation	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoleylation Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Drugs
Diseases			Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS		Height ( 31562340) Male-pattern baldness ( 28196072)
Interacting Genes		2 interacting genes: PORCN RHOU	6 interacting genes: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID		7475	64840
HPRD ID		05233	06680
Ensembl ID		ENSG00000115596	ENSG00000102312
Uniprot IDs		Q8N2E5 Q9Y6F9	Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
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