WAS and WIPF2

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
HPRD (in vitro, in vivo)

		WAS	WIPF2
Description		WASP actin nucleation promoting factor	WAS/WASL interacting protein family member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Actin Filament Plasma Membrane Cell-cell Junction Vesicle Membrane Actin Cytoskeleton Actin Cortical Patch Site Of Double-strand Break Phagocytic Vesicle Extracellular Exosome	Nucleoplasm Cytosol Actin Filament Plasma Membrane Actin Cortical Patch
	Molecular Function	Protein Binding SH3 Domain Binding Protein Kinase Binding GTPase Regulator Activity Small GTPase Binding Identical Protein Binding Phospholipase Binding Rac GTPase Binding Actin Filament Binding	Protein Binding Actin Filament Binding
	Biological Process	Actin Cortical Patch Assembly Regulation Of T Cell Antigen Processing And Presentation Endocytosis Defense Response Immune Response Rho Protein Signal Transduction Blood Coagulation Regulation Of Actin Polymerization Or Depolymerization Actin Polymerization Or Depolymerization Regulation Of Cell Shape Epidermis Development Regulation Of Lamellipodium Assembly Endosomal Transport Actin Filament Polymerization Actin Filament-based Movement Cdc42 Protein Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis T Cell Activation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity T Cell Receptor Signaling Pathway Positive Regulation Of Actin Nucleation Regulation Of Stress Fiber Assembly Negative Regulation Of Stress Fiber Assembly Actin Cortical Patch Localization Protein-containing Complex Assembly Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Negative Regulation Of Cell Motility Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Actin Cortical Patch Assembly Endocytosis Regulation Of Cell Shape Actin Filament-based Movement Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Actin Nucleation Actin Cortical Patch Localization
Pathways		Generation of second messenger molecules Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		(S)-Wiskostatin
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM) Neutropenic disorders, including the following three diseases: Kostmann syndrome; Cyclic neutropenia; X-linked neutropenia/myelodysplasia
GWAS			Asthma ( 31619474) Blond vs. brown/black hair color ( 30531825) Household income (MTAG) ( 31844048) PR interval in Tripanosoma cruzi seropositivity ( 24324551)
Interacting Genes		55 interacting genes: ABI3 ACTC1 APBB1 APPBP2 ARHGAP1 ARHGEF7 ARPC1B ARPC2 ARPC3 BAIAP2L1 BTK C5AR1 CDC42 CIB1 CRKL CSNK2A1 CSNK2A2 DLG1 DVL2 ENAH EVL FCHSD2 FGR FYB1 FYN GRB2 HCK HCLS1 ITK ITSN2 LCK LCP2 NCK1 NCK2 NCKIPSD PIK3R1 PLCG1 PRPF40A PSTPIP1 PTPN12 RAC1 RANBP2 RGS14 RHOJ SNX9 SORBS2 SRC TCERG1 TEC TNK2 TRIP10 VASP WBP4 WIPF1 WIPF2	10 interacting genes: APBB1 DNMBP GRB2 ITSN2 NCK2 PFN1 TCERG1 WAS WASL WWOX
Entrez ID		7454	147179
HPRD ID		02314	18304
Ensembl ID		ENSG00000015285	ENSG00000171475
Uniprot IDs		A0A024QYX8 P42768	Q8TF74
PDB IDs		1CEE 1EJ5 1T84 2A3Z 2K42 2OT0
Enriched GO Terms of Interacting Partners?
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