USP1 and FANCD2

Number of citations of the paper that reports this interaction (PubMedID 15694335)
205

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		USP1	FANCD2
Description		ubiquitin specific peptidase 1	FA complementation group D2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Thiol-dependent Ubiquitinyl Hydrolase Activity	Protein Binding DNA Polymerase Binding
	Biological Process	Skeletal System Development Regulation Of DNA Repair Ubiquitin-dependent Protein Catabolic Process Response To UV Protein Deubiquitination Monoubiquitinated Protein Deubiquitination Interstrand Cross-link Repair DNA Damage Response, Detection Of DNA Damage	Synapsis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases			Fanconi anemia
GWAS		Crohn's disease ( 26192919 28067908) Lipid traits ( 24386095) Metabolic syndrome ( 31589552) Regular attendance at a gym or sports club ( 29970889) Serum metabolite levels (CMS) ( 31636271) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		12 interacting genes: DTX3 FANCD2 FANCI KLHDC2 KPNA1 PCNA PHF7 TRAF6 TRIM46 UBB UBC UBE2K	28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1
Entrez ID		7398	2177
HPRD ID		04593	01968
Ensembl ID		ENSG00000162607	ENSG00000144554
Uniprot IDs		O94782	Q9BXW9
PDB IDs		6DO5
Enriched GO Terms of Interacting Partners?
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