CCT3 and EIF2B2

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCT3	EIF2B2
Description		chaperonin containing TCP1 subunit 3	eukaryotic translation initiation factor 2B subunit beta
Image
GO Annotations	Cellular Component	Zona Pellucida Receptor Complex Cytosol Chaperonin-containing T-complex Cytoskeleton Microtubule Plasma Membrane Cell Body Extracellular Exosome	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	RNA Binding Protein Binding ATP Binding Unfolded Protein Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Positive Regulation Of Telomere Maintenance Via Telomerase Pore Complex Assembly Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Recycling of eIF2:GDP
Drugs		Phosphoaminophosphonic Acid-Adenylate Ester Artenimol
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Glycated hemoglobin levels ( 24647736) Household income (MTAG) ( 31844048) Mean corpuscular hemoglobin concentration ( 20139978) Mean corpuscular volume ( 29403010) Red blood cell count ( 29403010) Subcutaneous adipose tissue ( 22589738)	Mood instability ( 29187730)
Interacting Genes		14 interacting genes: EIF2B2 FANCA HNRNPA0 HSPA8 LNX2 MAPK6 MIPOL1 PAFAH1B2 RAF1 SH3BP4 VAV2 VHL XRCC6 ZNRD2	12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 NPC2 PCGF6
Entrez ID		7203	8892
HPRD ID		08969	05923
Ensembl ID		ENSG00000163468	ENSG00000119718
Uniprot IDs		B3KX11 P49368 Q59H77	P49770 Q53XC2
PDB IDs		6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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