TPI1 and CCL11

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		TPI1	CCL11
Description		triosephosphate isomerase 1	C-C motif chemokine ligand 11
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cell
	Molecular Function	Triose-phosphate Isomerase Activity Protein Binding Methylglyoxal Synthase Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Gluconeogenesis Glycolytic Process Multicellular Organism Development Methylglyoxal Biosynthetic Process Glycerol Catabolic Process Glyceraldehyde-3-phosphate Biosynthetic Process Canonical Glycolysis	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline
Pathways		Glycolysis Gluconeogenesis	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		Zinc N-Hydroxy-4-Phosphono-Butanamide 2-Phosphoglycolic Acid Phosphoglycolohydroxamic Acid 3-(2-Benzothiazolylthio)-1-Propanesulfonic Acid [2(Formyl-Hydroxy-Amino)-Ethyl]-Phosphonic Acid Fluorotryptophane 2-Carboxyethylphosphonic Acid 2-Methyl-2-Propanol Dihydroxyacetone phosphate 1,4-Dithiothreitol 3-phospho-D-glyceric acid 3-(BUTYLSULPHONYL)-PROPANOIC ACID Artenimol	CAT-213
Diseases		Anemia due to disorders of glycolytic enzymes, including: Hexokinase (HK) deficiency; Phosphoglycerate kinase 1 (PGK1) deficiency; Triose-phosphate isomerase (TPI) deficiency; Glucose phosphate isomerase (GPI) deficiency; Bisphosphoglycerate mutase (BPGM) deficiency
GWAS		Blood protein levels ( 30072576)	Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		15 interacting genes: APP CCL11 CDKN2A CFL1 DDX24 EGFR LIPT1 MAPK6 PCNA POT1 SETDB1 SP1 TERF1 UCHL5 YWHAQ	7 interacting genes: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1
Entrez ID		7167	6356
HPRD ID		01833	03098
Ensembl ID		ENSG00000111669	ENSG00000172156
Uniprot IDs		P60174 Q53HE2 V9HWK1	P51671 Q6I9T4
PDB IDs		1HTI 1KLG 1KLU 1WYI 2IAM 2IAN 2JK2 2VOM 4BR1 4E41 4POC 4POD 4UNK 4UNL 4ZVJ 6C2G 6D43 6NLH	1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
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