TNFRSF1B and ZNF420

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		TNFRSF1B	ZNF420
Description		TNF receptor superfamily member 1B	zinc finger protein 420
Image			No pdb structure
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm	Nucleoplasm
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding	DNA Binding Protein Binding Metal Ion Binding
	Biological Process	Regulation Of T Cell Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Cytokine-mediated Signaling Pathway Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Neutrophil Degranulation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process	Regulation Of Transcription, DNA-templated Regulation Of Apoptotic Process
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Generic Transcription Pathway TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Drugs		Etanercept
Diseases		Graft-versus-host disease
GWAS		Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)	Prudent dietary pattern ( 28644415)
Interacting Genes		21 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	10 interacting genes: CDC42 CDK2AP1 CDKN2A CYP4V2 CYP51A1 HAX1 MDM2 SLC1A7 TNFRSF1B TRIM28
Entrez ID		7133	147923
HPRD ID		01862	08122
Ensembl ID		ENSG00000028137	ENSG00000197050
Uniprot IDs		P20333	Q8TAQ5
PDB IDs		1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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