CLEC3B and RPS6KA6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		CLEC3B	RPS6KA6
Description		C-type lectin domain family 3 member B	ribosomal protein S6 kinase A6
Image
GO Annotations	Cellular Component	Granular Component Extracellular Region Extracellular Space Cytoplasm Platelet Dense Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Calcium Ion Binding Heparin Binding Carbohydrate Binding Kringle Domain Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity ATP Binding
	Biological Process	Ossification Platelet Degranulation Positive Regulation Of Plasminogen Activation Bone Mineralization Cellular Response To Organic Substance Cellular Response To Transforming Growth Factor Beta Stimulus	Protein Phosphorylation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Signal Transduction Central Nervous System Development Intracellular Signal Transduction Negative Regulation Of Embryonic Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Mesoderm Development
Pathways		Platelet degranulation	Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation
Drugs		Tenecteplase Copper
Diseases
GWAS		Acne (severe) ( 24927181) Blood protein levels ( 30072576)
Interacting Genes		13 interacting genes: ANXA7 APP CDKN1A GADD45A GORASP1 GSK3B HGF PLAT PLG RPS6KA6 RPS6KB1 SH3GL2 TK1	27 interacting genes: ADIRF APP CEBPZ CENPB CLEC3B DHX34 DNAJC13 DNMT1 ERG28 FBN3 FZD5 LMO4 MASP1 MED24 MICAL1 MPP1 NR4A1 RBPJ RPLP1 RXRA SAP30BP SPTBN4 SYNE4 UBE2I UFM1 ZNF227 ZNF746
Entrez ID		7123	27330
HPRD ID		01759	02250
Ensembl ID		ENSG00000163815	ENSG00000072133
Uniprot IDs		E9PHK0 P05452	Q9UK32
PDB IDs		1HTN 1RJH 1TN3 3L9J	6G76 6G77 6G78
Enriched GO Terms of Interacting Partners?
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