TSPAN4 and CD46

Number of citations of the paper that reports this interaction (PubMedID 10741407)
30

Data Source:
HPRD (in vivo)

		TSPAN4	CD46
Description		tetraspanin 4	CD46 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Vesicle	Inner Acrosomal Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Extracellular Exosome
	Molecular Function	Antigen Binding Integrin Binding Protein Binding	Virus Receptor Activity Protein Binding Signaling Receptor Activity Cadherin Binding
	Biological Process	Protein-containing Complex Assembly	Adaptive Immune Response T Cell Mediated Immunity Complement Activation, Classical Pathway Single Fertilization Regulation Of Notch Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Complement Activation Interleukin-10 Production Positive Regulation Of Interleukin-10 Production Sequestering Of Extracellular Ligand From Receptor Positive Regulation Of T Cell Proliferation Positive Regulation Of Memory T Cell Differentiation Innate Immune Response Positive Regulation Of Regulatory T Cell Differentiation Viral Entry Into Host Cell Positive Regulation Of Transforming Growth Factor Beta Production
Pathways			Regulation of Complement cascade
Drugs
Diseases
GWAS			Age-related macular degeneration ( 23326517) Biomedical quantitative traits ( 19396169) Chronic central serous retinopathy ( 30073298) Drug experimentation measurement ( 30718321) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Heart rate ( 23583979) Immune response to measles vaccine (measles-specific neutralising antibody titre) ( 28289848) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Resting heart rate ( 29769521 27798624) Schizophrenia ( 25056061 29483656) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		9 interacting genes: CD46 CD81 CD9 CLDN11 CREB3 ITGA3 ITGA6 ITGB1 NOTCH2NLA	9 interacting genes: C3 DLG4 ITGB1 LLGL1 MSN PRKACA SRC TSPAN4 YES1
Entrez ID		7106	4179
HPRD ID		04033	00406
Ensembl ID		ENSG00000214063	ENSG00000117335
Uniprot IDs		A0A024RCE1 A8MVV6 O14817	P15529
PDB IDs			1CKL 1HR4 2O39 3INB 3L89 3O8E 5FO8
Enriched GO Terms of Interacting Partners?
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