NR2E1 and RERE

Number of citations of the paper that reports this interaction (PubMedID 16481466)
43

Data Source:
BioGRID (pull down)

		NR2E1	RERE
Description		nuclear receptor subfamily 2 group E member 1	arginine-glutamic acid dipeptide repeats
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Histone Deacetylase Complex Nucleus
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Behavioral Fear Response Aggressive Behavior Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Nervous System Development Visual Perception Dentate Gyrus Development Amygdala Development Olfactory Bulb Development Layer Formation In Cerebral Cortex Forebrain Generation Of Neurons Cerebral Cortex Neuron Differentiation Anterior Commissure Morphogenesis Cell Differentiation Extracellular Matrix Organization Somatic Stem Cell Population Maintenance Social Behavior Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Cell Fate Commitment Negative Regulation Of Neuron Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Astrocyte Differentiation Regulation Of Dendrite Morphogenesis Anatomical Structure Development Retina Development In Camera-type Eye Regulation Of Timing Of Neuron Differentiation Long-term Synaptic Potentiation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Stem Cell Proliferation	Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Cerebellar Purkinje Cell Layer Maturation Cerebellar Granule Cell Precursor Proliferation Radial Glia Guided Migration Of Purkinje Cell Branching Morphogenesis Of A Nerve Dendrite Morphogenesis Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Nuclear Receptor transcription pathway Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Asthma ( 31361310 30929738 31619474) Asthma (adult onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma and major depressive disorder ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Diastolic blood pressure ( 27841878) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Feeling miserable ( 29500382) Femoral neck bone mineral density ( 22504420) Heel bone mineral density ( 30598549 28869591) Hippocampal volume in normal cognition ( 29274321) Loneliness ( 31518406) Lymphocyte counts ( 27863252) Major depressive disorder ( 27479909) Medication use (adrenergics, inhalants) ( 31015401) Neutrophil percentage of granulocytes ( 27863252) Optic cup area ( 25631615 28073927) Schizophrenia ( 28991256 29483656 30285260) Smoking initiation ( 30617275) Smoking status (ever vs never smokers) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) Tonsillectomy ( 27182965 28928442) Total body bone mineral density ( 29304378) Upper eyelid morphology ( 29921221) Vertical cup-disc ratio ( 20548946 25241763) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Vitiligo ( 20410501 27723757) White blood cell count ( 27863252)
Interacting Genes		7 interacting genes: ATN1 BCL11A DNMT3L ERBIN KDM1A NSD1 RERE	20 interacting genes: ALG13 ATN1 CBFA2T2 ECM1 EFEMP1 EFEMP2 EHMT2 H3C14 KAT6A KRTAP4-12 LZTR1 NR2E1 PLSCR1 PRRC2A PRRC2B PSMA3 RBFOX2 TRIM22 TRIP6 ZMYND8
Entrez ID		7101	473
HPRD ID		07230	05566
Ensembl ID		ENSG00000112333	ENSG00000142599
Uniprot IDs		B6ZGT9 Q9Y466	Q9P2R6
PDB IDs		4XAJ	2YQK
Enriched GO Terms of Interacting Partners?
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