TFAM and PNP

Number of citations of the paper that reports this interaction (PubMedID 12068295)
186

Data Source:
HPRD (in vitro)

		TFAM	PNP
Description		transcription factor A, mitochondrial	purine nucleoside phosphorylase
Image
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Protein-containing Complex Mitochondrial Nucleoid	Extracellular Region Nucleus Cytoplasm Cytosol Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Mitochondrial Promoter Sequence-specific DNA Binding Transcription Coactivator Binding Chromatin Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding DNA Binding, Bending Heat Shock Protein Binding Sequence-specific DNA Binding	Nucleoside Binding Purine Nucleobase Binding Purine-nucleoside Phosphorylase Activity Drug Binding Phosphate Ion Binding Identical Protein Binding
	Biological Process	Mitochondrial Transcription Transcription Initiation From Mitochondrial Promoter Mitochondrion Organization Mitochondrial Respiratory Chain Complex Assembly Positive Regulation Of Transcription, DNA-templated	Nucleobase-containing Compound Metabolic Process Inosine Catabolic Process Purine Nucleotide Catabolic Process Nicotinamide Riboside Catabolic Process Immune Response Nucleotide Biosynthetic Process Urate Biosynthetic Process Positive Regulation Of T Cell Proliferation Response To Drug Purine-containing Compound Salvage Neutrophil Degranulation Positive Regulation Of Alpha-beta T Cell Differentiation Interleukin-2 Secretion
Pathways		Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis	Neutrophil degranulation Purine salvage Purine catabolism
Drugs			Cladribine Didanosine 8-azaguanine 2,6-Diamino-(S)-9-[2-(Phosphonomethoxy)Propyl]Purine Immucillin-G Guanine 2-Amino-7-[2-(2-Hydroxy-1-Hydroxymethyl-Ethylamino)-Ethyl]-1,7-Dihydro-Purin-6-One Peldesine 9-Deazainosine Guanosine Ribose-1-Phosphate 4'-Deaza-1'-Aza-2'-Deoxy-1'-(9-Methylene)-Immucillin-H, (3r,4r)-N-[9-Deazahypoxanthin-9-Yl)Methyl]-4-Hydroxymethyl-Pyrrolidin-3-Ol 3-Deoxyguanosine MT-Immucillin-H Hypoxanthine 9-(5,5-Difluoro-5-Phosphonopentyl)Guanine Inosine 9-DEAZAINOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-ETHYLIDENEPHOSPHONATE GUANOSINE-2',3'-O-METHYLIDENEPHOSPHONATE
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Blood urea nitrogen levels ( 29403010) Height ( 23456168) Metabolite levels ( 23823483) Midgestational circulating levels of PCBs ( 28235828)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Blood protein levels ( 30072576) Interferon alpha levels in systemic lupus erythematosus ( 25338677) Menopause (age at onset) ( 26414677)
Interacting Genes		5 interacting genes: AGTRAP ARL6IP1 PNP TFB1M TFB2M	11 interacting genes: APLP1 CCDC90B LRIF1 NCALD NOS1AP RBM48 TFAM TFB2M TP53 UCHL5 ZHX1
Entrez ID		7019	4860
HPRD ID		02702	01247
Ensembl ID		ENSG00000108064	ENSG00000198805
Uniprot IDs		E5KSU5 Q00059	P00491 V9HWH6
PDB IDs		3FGH 3TMM 3TQ6 4NNU 4NOD 6ERP 6ERQ 6HB4 6HC3	1M73 1PF7 1PWY 1RCT 1RFG 1RR6 1RSZ 1RT9 1ULA 1ULB 1V2H 1V3Q 1V41 1V45 1YRY 2A0W 2A0X 2A0Y 2OC4 2OC9 2ON6 2Q7O 3BGS 3D1V 3GB9 3GGS 3INY 3K8O 3K8Q 3PHB 4EAR 4EB8 4ECE 4GKA 5ETJ 5UGF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?