TCF7L2 and KMT5A

Number of citations of the paper that reports this interaction (PubMedID 21282610)
60

Data Source:
BioGRID (affinity chromatography technology, pull down, affinity chromatography technology)

		TCF7L2	KMT5A
Description		transcription factor 7 like 2	lysine methyltransferase 5A
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex PML Body Protein-DNA Complex Beta-catenin-TCF7L2 Complex	Nucleoplasm Chromosome Cytosol
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Nuclear Hormone Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Gamma-catenin Binding Armadillo Repeat Domain Binding	P53 Binding Transcription Corepressor Activity Protein Binding Lysine N-methyltransferase Activity Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H4-K20 Specific)
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cell Cycle Arrest Wnt Signaling Pathway, Calcium Modulating Pathway Response To Glucose Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Wnt Signaling Pathway Pancreas Development Positive Regulation Of Insulin Secretion Positive Regulation Of Protein Binding Regulation Of Hormone Metabolic Process Glucose Homeostasis Negative Regulation Of DNA-binding Transcription Factor Activity Maintenance Of DNA Repeat Elements Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Export From Nucleus Myoblast Fate Commitment Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Canonical Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Cell Cycle Peptidyl-lysine Monomethylation Histone H4-K20 Methylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Transcription, DNA-templated Cell Division Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes TCF7L2 mutants don't bind CTBP Transcriptional Regulation by VENTX RUNX3 regulates WNT signaling	Condensation of Prophase Chromosomes PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation
Drugs
Diseases		Type II diabetes mellitus
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Bipolar disorder (body mass index interaction) ( 24322204) Blood glucose levels ( 29615537) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26426971 31453325 28892062 25673413 28448500) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 23535729 27117709) Breast Cancer in BRCA1 mutation carriers ( 23544013) Clinical laboratory measurements ( 27897004) Cognitive decline (age-related) ( 28078323) Colorectal cancer ( 30529582 24836286 29471430) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood insulin ( 22581228) Fasting blood insulin (BMI interaction) ( 22581228) Glucosuria ( 30476138) Glucosuria (mild) ( 30476138) Glucosuria (moderate to severe) ( 30476138) Glycated hemoglobin levels ( 20849430 28898252) Glycemic traits (pleiotropy) ( 31021400) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Hemoglobin A1c levels ( 29403010) Hip circumference ( 25673412) Intraocular pressure ( 29617998 29785010) Ischemic stroke ( 26732560) Medication use (drugs used in diabetes) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252) Myopia ( 27182965) Offspring birth weight ( 31043758) Peak insulin response ( 28490609) Peripheral artery disease ( 31285632) Proinsulin levels ( 21873549) Prostate cancer ( 29892016) Pulse pressure ( 27841878 30578418) Schizophrenia vs type 2 diabetes ( 30470734) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878 30578418) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 27189021 17668382 22885922 18372903 24509480 17293876 30054458 30470734 22693455 26961502 31324766 29358691 25102180 30297969 19734900 28254843 25483131 17554300 26818947 31049640 23945395 31118516 23300278 20581827 19401414 24390345 17463246 30718926 17463248 17463249 22101970 21347282 28869590 17460697 19056611 23209189) Urate levels ( 31578528) Waist circumference ( 25673412) Waist-to-hip ratio adjusted for body mass index ( 28430825)	Autism spectrum disorder or schizophrenia ( 28540026) High density lipoprotein cholesterol levels ( 29403010)
Interacting Genes		20 interacting genes: AR CCNG2 CSNK2A1 CSNK2A2 CTNNB1 CTNNBIP1 DAXX DAZAP2 EP300 FBLN1 HIC1 JUP KCNE4 KMT5A MEN1 PSEN1 PSMA3 RBPMS RNF138 TLE3	9 interacting genes: BTRC DTL E2F2 FAM9A H4-16 TCF7L2 TP53 TWIST1 UBE2I
Entrez ID		6934	387893
HPRD ID		03751	06254
Ensembl ID		ENSG00000148737	ENSG00000183955
Uniprot IDs		A0A0A0MTL7 C6ZRJ7 C6ZRK1 C6ZRK2 C6ZRK5 Q5VVR7 Q6FHW4 Q9NQB0	E3VVS3 Q9NQR1
PDB IDs		1JDH 1JPW 2GL7	1ZKK 2BQZ 3F9W 3F9X 3F9Y 3F9Z 4IJ8 5HQ2 5T5G 5TEG 5TH7 5V2N 5W1Y 6BOZ
Enriched GO Terms of Interacting Partners?
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