TCF7 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 28198400)
2

Data Source:
BioGRID (enzymatic study)

		TCF7	UCHL5
Description		transcription factor 7	ubiquitin C-terminal hydrolase L5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Nuclear Euchromatin Nuclear Body	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Ino80 Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Bacterial-type RNA Polymerase Transcriptional Repressor Activity, Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Endopeptidase Inhibitor Activity Protein Binding Proteasome Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Immune Response Wnt Signaling Pathway Neural Tube Development Embryonic Genitalia Morphogenesis T Cell Receptor V(D)J Recombination Regulation Of Cell Proliferation Canonical Wnt Signaling Pathway Involved In Negative Regulation Of Apoptotic Process Alpha-beta T Cell Differentiation Embryonic Digestive Tract Morphogenesis Embryonic Hindgut Morphogenesis Canonical Wnt Signaling Pathway Cellular Response To Interleukin-4 Beta-catenin-TCF Complex Assembly	DNA Repair DNA Recombination Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Endopeptidase Activity Protein Deubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Ca2+ pathway Binding of TCF/LEF:CTNNB1 to target gene promoters Repression of WNT target genes Repression of WNT target genes RUNX3 regulates WNT signaling	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Medication use (thyroid preparations) ( 31015401) Menarche (age at onset) ( 25231870) Multiple sclerosis ( 31604244 24076602 21833088) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26502338 28714469) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Cannabis dependence ( 21668797)
Interacting Genes		3 interacting genes: GOLGA3 SS18L1 UCHL5	101 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4-16 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		6932	51377
HPRD ID		01797	10293
Ensembl ID		ENSG00000081059	ENSG00000116750
Uniprot IDs		B3KQ75 P36402	Q9Y5K5
PDB IDs			3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?
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