TCF3 and LMX1B

Number of citations of the paper that reports this interaction (PubMedID 9199284)
18

Data Source:
HPRD (in vitro)

		TCF3	LMX1B
Description		transcription factor 3	LIM homeobox transcription factor 1 beta
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Enhancer Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding Vitamin D Response Element Binding E-box Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Lineage Commitment Transcription, DNA-templated Regulation Of Transcription, DNA-templated B Cell Differentiation Immunoglobulin V(D)J Recombination Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Regulation Of Hematopoietic Stem Cell Differentiation	In Utero Embryonic Development Regulation Of Transcription, DNA-templated Multicellular Organism Development Dorsal/ventral Pattern Formation Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Dopaminergic Neuron Differentiation
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Hodgkin's lymphoma ( 29196614 24920014) Objective response to lithium treatment ( 26503763)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Body fat mass ( 28552196) Body mass index ( 28552196 26961502 28892062 25673413 20935630) Breast cancer ( 29059683 31757997) Calcium levels ( 29403010) Childhood body mass index ( 26604143) Chin dimples ( 27182965) Eyebrow thickness ( 26926045) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 29449654) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29785010 31959993 30054594) Medication use (antiglaucoma preparations and miotics) ( 31015401) Monobrow ( 27182965) Multiple system atrophy ( 27629089) Open-angle glaucoma and optic cup area ( 29449654) Osteoarthritis (hip) ( 30374069) Social communication problems ( 24564958) Trunk fat mass ( 28552196)
Interacting Genes		66 interacting genes: AEBP1 ASCL3 AURKA BHLHA15 BHLHE40 CALM1 CALM3 CBFA2T3 CREBBP CTNNB1 DACH1 DAXX ELK3 EP300 FERD3L GLIS1 HAND1 HAND2 HOXA1 ID1 ID2 ID3 KAT2A KAT2B LMX1A LMX1B LYL1 MAPK1 MAPK3 MAPKAPK2 MAPKAPK3 MDFI MEN1 MSC MYF5 MYF6 MYOD1 MYOG NEDD9 NEUROD1 NHLH1 NSD3 PARP1 PDX1 PSMD4 PSMD9 RALGAPA1 RPL37 RUNX1T1 SCX SKP2 SRF SUPT3H TADA2A TAL1 TAL2 TCAF1 TCF12 TCF21 TCF4 TFPT TLE1 TRRAP TWIST1 UBE2I USF1	3 interacting genes: APP LDB1 TCF3
Entrez ID		6929	4010
HPRD ID		00918	03986
Ensembl ID		ENSG00000071564	ENSG00000136944
Uniprot IDs		A0A0A0MRB7 P15923 X6REB3	B7ZLH2 O60663 Q6ISE0
PDB IDs		1HLH 2MH0 2YPA 2YPB 3U5V 6MGN
Enriched GO Terms of Interacting Partners?
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