STAT2 and TYK2

Number of citations of the paper that reports this interaction (PubMedID 8605877)
39

Data Source:
HPRD (in vitro, in vivo)

		STAT2	TYK2
Description		signal transducer and activator of transcription 2	tyrosine kinase 2
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Type 1 Angiotensin Receptor Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Transcription By RNA Polymerase II Defense Response JAK-STAT Cascade Viral Process Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Type I Interferon Signaling Pathway Regulation Of Mitochondrial Fission	Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-23-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-27-mediated Signaling Pathway
Pathways		Interleukin-20 family signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Other interleukin signaling Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interleukin-20 family signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling Interleukin-23 signaling Interleukin-23 signaling Interleukin-27 signaling Interleukin-27 signaling Interferon alpha/beta signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs			2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Tofacitinib
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS		Axial length ( 24144296) Height ( 20881960 25429064 23456168) Inflammatory skin disease ( 25574825) Macular thickness ( 30535121) Psoriasis ( 25903422 25574825 23143594 19169254) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624)	Ankylosing spondylitis ( 23749187) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lymphocyte counts ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 24076602 21833088) Neutrophil percentage of white cells ( 27863252) Pediatric autoimmune diseases ( 26301688) Platelet count ( 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Psoriasis ( 20953190 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624) Rheumatoid arthritis ( 30423114 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sarcoidosis ( 26051272) Systemic lupus erythematosus ( 27399966 26502338 28714469) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Type 1 diabetes ( 21829393 25751624 19966805) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)
Interacting Genes		20 interacting genes: AURKA CREBBP CXCR4 DOK4 EGFR EP300 FNTA GAA HDAC1 IFNAR1 IFNAR2 IRF9 IWS1 JAK1 JAK2 MED14 SMARCA4 STAT1 STAT6 TYK2	37 interacting genes: CBL COPS5 CRKL DNM2 EIF2AK2 FHL3 FYN GHR HNRNPK IFNAR1 IFNAR2 IL13RA1 IL6ST IRS1 IRS2 JAK1 JAKMIP1 KHDRBS2 KRT40 LYN PDGFRB PIK3R1 PLAUR PRMT5 PTAFR PTPN1 PTPN6 PTPRC RACK1 SOCS1 STAM2 STAT1 STAT2 TK1 TRAF4 VAV1 XRCC5
Entrez ID		6773	7297
HPRD ID		02778	01490
Ensembl ID		ENSG00000170581	ENSG00000105397
Uniprot IDs		P52630 R9QE65	A0A024R7E4 P29597
PDB IDs		2KA4	3LXN 3LXP 3NYX 3NZ0 3ZON 4GFO 4GIH 4GII 4GJ2 4GJ3 4GVJ 4OLI 4PO6 4PY1 4WOV 5C01 5C03 5F1Z 5F20 5TKD 5WAL 6AAM 6DBK 6DBM 6NZE 6NZF 6NZH 6NZP 6NZQ 6NZR
Enriched GO Terms of Interacting Partners?
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