SRP14 and TLE3

		SRP14	TLE3
Description		signal recognition particle 14	TLE family member 3, transcriptional corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Secretory Granule Lumen Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Transcription Factor Complex Beta-catenin-TCF Complex
	Molecular Function	RNA Binding Protein Binding 7S RNA Binding Endoplasmic Reticulum Signal Peptide Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane Response To Drug Neutrophil Degranulation Protein Targeting To ER	Regulation Of Transcription, DNA-templated Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Nucleic Acid-templated Transcription Beta-catenin-TCF Complex Assembly
Pathways		SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Neutrophil degranulation	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs		Artenimol
Diseases
GWAS		Ewing sarcoma ( 22327514) Obesity-related traits ( 23251661)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 31562340) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 30046033) Pulmonary function ( 23932459) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Schizophrenia ( 25056061 29483656 30285260) Serum total protein level ( 29403010) Triglyceride levels ( 29403010) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500)
Interacting Genes		5 interacting genes: CALM1 IL7R NSFL1C SRP9 TLE3	19 interacting genes: APP BIRC5 BMP3 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP NDRG1 NOTCH1 PIN1 RPL4 SIX3 SRP14 TAOK2 TCF7L2 XIAP
Entrez ID		6727	7090
HPRD ID		02831	02558
Ensembl ID		ENSG00000140319	ENSG00000140332
Uniprot IDs		P37108	B3KUA2 F5H7D6 H0YL70 Q04726 Q6PRX3
PDB IDs		1E8O 1E8S 1RY1 4UYJ 4UYK 5AOX
Enriched GO Terms of Interacting Partners?
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