SRI and PDE4C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SRI	PDE4C
Description		sorcin	phosphodiesterase 4C
Image
GO Annotations	Cellular Component	Cell Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Cytosol Membrane Sarcoplasmic Reticulum Z Disc T-tubule Sarcoplasmic Reticulum Membrane Chromaffin Granule Membrane Axon Terminus Dendritic Spine Neck Extracellular Exosome	Extracellular Space Cytosol Cilium
	Molecular Function	Protease Binding Signaling Receptor Binding Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Ion Channel Binding Protein Heterodimerization Activity Repressing Transcription Factor Binding	3',5'-cyclic-AMP Phosphodiesterase Activity Metal Ion Binding
	Biological Process	Action Potential Calcium Ion Transport Intracellular Sequestering Of Iron Ion Regulation Of Striated Muscle Contraction Signal Transduction Heart Development Muscle Organ Development Regulation Of Heart Contraction Negative Regulation Of Heart Rate Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cytoplasmic Sequestering Of Transcription Factor Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transport Negative Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cardiac Muscle Cell Contraction Regulation Of Relaxation Of Muscle Regulation Of High Voltage-gated Calcium Channel Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Negative Regulation Of Transcription Regulatory Region DNA Binding	CAMP Catabolic Process G Protein-coupled Receptor Signaling Pathway
Pathways		Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	DARPP-32 events G alpha (s) signalling events
Drugs		Calcium Citrate Calcium Phosphate	Caffeine Dyphylline Iloprost Roflumilast Piclamilast Crisaborole Ibudilast Trapidil
Diseases
GWAS			Urate levels ( 31578528)
Interacting Genes		19 interacting genes: ALG2 ANXA11 ANXA7 CACNA1C CACNA1S CALCOCO2 GCA MTNR1A NRAS PDE4C PRR13 PSEN2 RYR2 SHBG SMAD2 SNCA SRPK2 STAT3 TCF12	2 interacting genes: GDF15 SRI
Entrez ID		6717	5143
HPRD ID		01680	02529
Ensembl ID		ENSG00000075142	ENSG00000105650
Uniprot IDs		B4DHQ6 C9J0K6 P30626	O43849 P78505 Q08493 Q32MM7 Q7KYS4
PDB IDs		1JUO 2JC2 4U8D 4UPG 4USL 5MRA	1LXU 2QYM
Enriched GO Terms of Interacting Partners?
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