SRC and FHIT

  • Number of citations of the paper that reports this interaction (PubMedID 15835917)
  • 5
  • Data Source:
  • HPRD (in vitro, in vivo)

SRC

FHIT

Description SRC proto-oncogene, non-receptor tyrosine kinase fragile histidine triad diadenosine triphosphatase
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Adverse response to lamotrigine and phenytoin ( 22379998)
  • Aortic root size ( 21223598)
  • Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598)
  • Asperger disorder ( 21182207)
  • Attention deficit hyperactivity disorder ( 18821565)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Blood pressure ( 24954895)
  • Blood protein levels ( 30072576)
  • BMI (adjusted for smoking behaviour) ( 28443625)
  • BMI in non-smokers ( 28443625)
  • BMI in smokers ( 28443625)
  • Body mass index ( 28552196 26961502 28892062 25673413 28448500)
  • Body mass index (joint analysis main effects and physical activity interaction) ( 28448500)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Body mass index in physically active individuals ( 28448500)
  • Broad depression or schizophrenia ( 30626913)
  • Bronchopulmonary dysplasia ( 23897914)
  • Caudal anterior-cingulate cortex volume ( 31530798)
  • Cognitive function ( 25644384)
  • Conotruncal heart defects ( 24800985)
  • Depressive symptom measurement or major depressive disorder ( 28049566)
  • Differentiated thyroid cancer ( 28703219)
  • HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Hip circumference ( 28552196)
  • Intracranial aneurysm ( 29531279)
  • Iris color (L* coordinate) ( 30895295)
  • Irritable bowel syndrome ( 29673008)
  • Lung function (maximal voluntary ventilation) ( 29095316)
  • Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643)
  • Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643)
  • Major depressive disorder ( 20125088)
  • Methadone dose in opioid dependence ( 28115739)
  • Myopia (pathological) ( 23049088)
  • Orofacial clefts ( 22419666)
  • Papillary thyroid cancer ( 28703219)
  • Pars triangularis volume ( 31530798)
  • Photic sneeze reflex ( 27182965)
  • Postoperative myocardial infarction after cardiac surgery ( 30678657)
  • Response to amphetamines ( 22952603)
  • Response to citalopram treatment ( 22760553)
  • Schizophrenia ( 30285260)
  • Urinary metabolite levels in chronic kidney disease ( 29545352)
  • Waist circumference ( 28552196)
  • Weight ( 28552196)
Interacting Genes 278 interacting genes: ABL1 ACTN1 ADAM12 ADAM15 ADRB2 ADRB3 AFAP1 AFAP1L2 AGAP1 AKT1 ANKRD11 ANXA1 ANXA2 ANXA7 AR ARHGAP1 ARHGAP17 ARHGAP32 ARHGAP35 ARR3 ASAP1 ATG9A ATP2B4 AXL BCAR1 BCCIP BCR BMX CA3 CAV1 CAV2 CBL CBLC CCNA1 CD2AP CD33 CD36 CD44 CD46 CD59 CDC25A CDC37 CDCP1 CDH5 CDK5 CDKN1B CEACAM1 CEACAM3 CFL1 CHUK CLTC CNTNAP1 COASY CORO7 CRMP1 CSK CTNNB1 CTNND1 CTTN DAB1 DAB2 DAG1 DAPP1 DDR2 DGKA DGKZ DLG4 DNM1 DNM2 DOK1 DOK2 DOK4 EFNA5 EFNB1 EFNB2 EFS EGFR EGLN1 EMD ENO1 EPHA3 EPHA4 EPHB2 EPS8 ERBB2 ERBB3 ERRFI1 ESR1 ESR2 ETS1 ETS2 EVL FARP2 FASLG FBXO5 FGR FHIT FLNA FLT3 FOXO1 FRS2 FYB1 GAB2 GAB3 GFAP GIT1 GJA1 GJB1 GRB10 GRB2 GRIN2A GRIN2B GRK2 GTF2I GUCY2C HDAC3 HLA-A HLA-B HNF1A HNRNPK HRAS HSP90AA1 IGF1R IKBKB IKBKG IL6R INPPL1 INSR ITGB3 ITK JUP KCNA5 KCNB1 KCNQ5 KDR KHDRBS1 KIFAP3 KIT LRP1 LYN MAP2 MAPK15 MAPK8IP3 MAPRE1 MAPT MATK MDM2 MED28 MET MICAL1 MPZL1 MST1R MT-ND2 MUC1 MYLK NCOA6 NEDD4 NFKBIA NMT1 NOS2 NPHS1 NR1I2 NR1I3 NR3C1 P2RY2 PAK2 PDCD6IP PDE4D PDE6G PDGFRB PDPK1 PECAM1 PELP1 PGR PIK3R1 PIK3R3 PIP5K1C PKD1 PLCG1 PLD1 PLD2 PLSCR1 PPARD PPARGC1B PRKACA PRKCA PRKCD PRKCE PRKCH PRKCI PRKCZ PRKD1 PROM1 PTK2 PTK2B PTPA PTPN1 PTPN11 PTPN18 PTPN2 PTPN21 PTPN6 PTPRA PTPRC PTPRE PXN RACK1 RAF1 RARA RASA1 RASGRF1 RET RGS16 RPL10 RPS6KA3 RPS6KB1 RPS6KB2 RXRA SH2D3C SH3BP1 SH3PXD2A SHB SHC1 SKAP1 SKAP2 SLC9A2 SMARCB1 SMARCE1 SNCA SORBS1 SPTAN1 SRCIN1 SRF SRPK2 STAP2 STAT1 STAT3 STAT5A STAT5B STAT6 STUB1 SYK SYN1 TAMALIN TERT THRA THRB TIAM1 TMPO TNFRSF11A TNFRSF1A TNK2 TP53 TRAF1 TRAF3 TRAF6 TRAT1 TRIM50 TRIP10 TRIP6 TRPC6 TRPV4 TUB TXK TYRO3 USP8 VCL VDR VIL1 WAS WASL WBP11 WWOX YTHDC1 YWHAB YWHAE YWHAG YWHAH 9 interacting genes: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I
Entrez ID 6714 2272
HPRD ID 01819 03096
Ensembl ID ENSG00000197122 ENSG00000189283
Uniprot IDs P12931 A0A024R366 P49789
PDB IDs 1A07 1A08 1A09 1A1A 1A1B 1A1C 1A1E 1FMK 1HCS 1HCT 1KSW 1O41 1O42 1O43 1O44 1O45 1O46 1O47 1O48 1O49 1O4A 1O4B 1O4C 1O4D 1O4E 1O4F 1O4G 1O4H 1O4I 1O4J 1O4K 1O4L 1O4M 1O4N 1O4O 1O4P 1O4Q 1O4R 1SHD 1Y57 1YI6 1YOJ 1YOL 1YOM 2BDF 2BDJ 2H8H 2SRC 3VRO 3ZMP 3ZMQ 4F59 4F5A 4F5B 4HXJ 4K11 4MXO 4MXX 4MXY 4MXZ 6ATE 6C4S 6E6E 6EHJ 1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?
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