SNX2 and PAK6

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SNX2	PAK6
Description		sorting nexin 2	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Endosome Cytosol Endosome Membrane Membrane Lamellipodium Retromer Complex Retromer, Tubulation Complex Early Endosome Membrane Protein-containing Complex	Fibrillar Center Nucleoplasm Cytoplasm Cell Junction
	Molecular Function	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Cadherin Binding Protein Heterodimerization Activity Transferrin Receptor Binding Leptin Receptor Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding
	Biological Process	Intracellular Protein Transport Endocytosis Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Lamellipodium Morphogenesis	Regulation Of Transcription, DNA-templated Apoptotic Process Cytoskeleton Organization Regulation Of Mitotic Cell Cycle Learning Memory Locomotory Behavior Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity
Pathways		Golgi Associated Vesicle Biogenesis	Activation of RAC1
Drugs
Diseases
GWAS		Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy ( 26460308)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656)
Interacting Genes		20 interacting genes: ACVR1B ACVR2B C1orf122 CSNK2B DUSP10 EGFR FNBP1 INSR LAMC1 LEPR MET NFYC PAK6 PDGFRA PDGFRB SNX1 SNX4 SNX5 SNX6 ZNF202	18 interacting genes: APP AR CDC42 CDK1 DAPK1 ESR1 FBXO7 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ SEMA3B SNX2 TPD52L1
Entrez ID		6643	56924
HPRD ID		09332	06426
Ensembl ID		ENSG00000205302	ENSG00000137843
Uniprot IDs		O60749	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8
Enriched GO Terms of Interacting Partners?
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