SMN1 and SULT1A3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		SMN1	SULT1A3
Description		survival of motor neuron 1, telomeric	sulfotransferase family 1A member 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cajal Body Nuclear Body Z Disc Axon SMN Complex SMN-Sm Protein Complex Cytoplasmic Ribonucleoprotein Granule Neuron Projection Perikaryon Gemini Of Coiled Bodies	Cytosol
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Aryl Sulfotransferase Activity Protein Binding Sulfotransferase Activity Sulfate Binding Amine Sulfotransferase Activity
	Biological Process	Spliceosomal Complex Assembly Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Nervous System Development Import Into Nucleus	Ethanol Catabolic Process Xenobiotic Metabolic Process Dopamine Receptor Signaling Pathway Steroid Metabolic Process Flavonoid Metabolic Process IRE1-mediated Unfolded Protein Response Dopamine Catabolic Process 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation ERK1 And ERK2 Cascade Calcineurin-mediated Signaling NMDA Selective Glutamate Receptor Signaling Pathway Negative Regulation Of Neuron Death Cellular Response To Dopamine
Pathways		snRNP Assembly	Cytosolic sulfonation of small molecules XBP1(S) activates chaperone genes Cytosolic sulfonation of small molecules
Drugs		Nusinersen
Diseases		Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Interacting Genes		149 interacting genes: A1BG A2M ACTB ACTL6B ADAMTS10 AGAP1 ANXA2 APLP1 ARFGAP1 ATP5F1B ATP6V1A BAG6 BCL2 C9orf72 CARHSP1 CCDC90B CENPB COIL COL4A2 COL4A5 COPS6 CPNE6 CRIP2 CSAD DDAH2 DDX20 DHX9 DMPK DOCK7 DUS2 DYNC1I1 EEF1A1 EEF1A2 EIF3G EXT2 EZH2 FAM20C FBL FGB FLAD1 FUBP1 GAPDH GAR1 GDF9 GEMIN2 GEMIN5 GEMIN7 H3-4 HADHB HMGXB3 HNRNPR HNRNPU HNRNPUL1 IGHM ILF3 IMMT INPP5K ITCH JADE1 KDM1A KIF5A KLHL5 KMT2B KPNB1 LENG8 LRIF1 LSM1 LSM10 LSM11 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MAST2 MED31 MKI67 MPP1 MRPL37 MSH2 NGFR NKIRAS2 NMT2 NRN1 NTAQ1 OSTF1 PDE4DIP PKM PLXNA3 POLR2A POP7 PPIG PSME1 QARS1 RBBP4 RBBP6 RBFOX2 RBM48 REX1BD RN7SL1 RNU1-1 RNU11 RNU2-1 RNU4-1 RPL13 RPS2 RXRA SCARNA1 SDF4 SELENOW SEMA5B SETDB1 SMC5 SMN2 SNORA81 SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNUPN SP110 STRAP STXBP2 STXBP3 SULT1A3 SUMO3 SYNCRIP TAF1C TERC TIAL1 TLE1 TMSB4X TP53 TRMT2A TUBA1A TUBB3 UCHL1 UNC119 USP4 VPS28 WDR18 WDR73 WIZ ZBTB16 ZNF431 ZRANB2 ZXDC	6 interacting genes: APP KHDRBS2 NIF3L1 SHMT1 SMN1 TK1
Entrez ID		6606	6818
HPRD ID		02646	07199
Ensembl ID		ENSG00000172062	ENSG00000261052
Uniprot IDs		B4DP61 E7EQZ4 Q16637	P0DMM9 P0DMN0 Q1ET61
PDB IDs		1G5V 1MHN 2LEH 4A4E 4A4G 4GLI 4QQ6 5XJL 5XJQ 5XJR 5XJS 5XJT 5XJU	1CJM 2A3R
Enriched GO Terms of Interacting Partners?
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