SMARCA2 and CEBPA

Number of citations of the paper that reports this interaction (PubMedID 15107404)
51

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		SMARCA2	CEBPA
Description		SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	CCAAT enhancer binding protein alpha
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm SWI/SNF Complex Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton NpBAF Complex NBAF Complex	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Transcription Coactivator Activity Helicase Activity Protein Binding ATP Binding DNA-dependent ATPase Activity Histone Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Kinase Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Remodeling Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Spermatid Development Nervous System Development Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Urea Cycle Negative Regulation Of Transcription By RNA Polymerase II Liver Development Embryonic Placenta Development Generation Of Precursor Metabolites And Energy Transcription, DNA-templated Transcription By RNA Polymerase II Mitochondrion Organization Notch Signaling Pathway Cholesterol Metabolic Process Negative Regulation Of Cell Proliferation Viral Process Cytokine-mediated Signaling Pathway Myeloid Cell Differentiation Macrophage Differentiation Lung Development Granulocyte Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Glucose Homeostasis Positive Regulation Of Macrophage Activation Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Cell Maturation Inner Ear Development Positive Regulation Of Inflammatory Response White Fat Cell Differentiation Brown Fat Cell Differentiation Lipid Homeostasis Interleukin-6-mediated Signaling Pathway Cellular Response To Lithium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS		Adverse response to chemotherapy in breast cancer (alopecia) (cyclophosphamide+doxorubicin+/-5FU) ( 24025145) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma (childhood onset) ( 27611488) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Lead levels ( 26025379) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Monobrow ( 27182965) Neuritic plaque ( 31497858) Nose size ( 27182965) Parkinson's disease ( 26227905) Superior frontal gyrus grey matter volume ( 25335168) Systolic blood pressure ( 26969751)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 30929738) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Red blood cell count ( 29403010) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500) White blood cell count (basophil) ( 29403010 28158719)
Interacting Genes		27 interacting genes: ACTL6A ACTL6B AR ARID1B BEND7 BRCA1 CEBPA ESR1 H3C1 HSPB1 KHDRBS1 MDM2 MDM4 MECP2 MYB MYC NR0B2 NR3C1 NR4A2 PHB PITX1 PRMT5 PRPF6 RAP1A SDCBP SIN3B SS18	58 interacting genes: AR ATF2 ATF3 ATF4 ATF5 BATF BATF2 BATF3 C1QBP CDK2 CDK4 CDKN1A CDKN3 CDX1 CEBPB CEBPD CEBPE CEBPG CREBBP CTNNB1 DBP DDIT3 EDF1 EP300 ESR1 FOS FOSL1 GATA2 GSK3B HNF1A MAPK8 MSX2 MYC NCOA6 NFYA NR3C1 PIAS1 PPP2CA RARA RARB RASGRF1 RB1 RBL1 RFC1 RUNX1 SKP2 SMAD3 SMAD4 SMARCA2 SMARCA4 SOX10 SOX8 SPI1 SRA1 SUMO3 XRCC5 XRCC6 ZBTB16
Entrez ID		6595	1050
HPRD ID		02483	00296
Ensembl ID		ENSG00000080503	ENSG00000245848
Uniprot IDs		B1ALF6 B4DNT1 B4DSC8 F6T8Q0 F6VDE0 P51531 Q56A76 Q8N9Q1	P49715
PDB IDs		2DAT 4QY4 5DKC 5DKH 6EG2 6EG3 6HAX 6HAY 6HAZ	6DC0
Enriched GO Terms of Interacting Partners?
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