SLC22A2 and HYAL3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SLC22A2	HYAL3
Description		solute carrier family 22 member 2	hyaluronidase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Exosome Presynapse	Acrosomal Vesicle Acrosomal Membrane Extracellular Region Lysosome Early Endosome Endoplasmic Reticulum Plasma Membrane Cytoplasmic Vesicle Sperm Midpiece
	Molecular Function	Organic Cation Transmembrane Transporter Activity	Virus Receptor Activity Hyalurononglucosaminidase Activity Protein Binding Hyaluronoglucuronidase Activity
	Biological Process	Drug Transmembrane Transport Neurotransmitter Secretion Body Fluid Secretion Organic Cation Transport Neurotransmitter Biosynthetic Process	Ovarian Follicle Atresia Carbohydrate Metabolic Process Inflammatory Response Penetration Of Zona Pellucida Response To Virus Hyaluronan Catabolic Process Response To Antibiotic Viral Entry Into Host Cell Cartilage Development Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To UV-B Negative Regulation Of Ovarian Follicle Development Positive Regulation Of Acrosomal Vesicle Exocytosis
Pathways		Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport	CS/DS degradation Hyaluronan uptake and degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971 25673413) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 31152163 20383146) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31152163 31015462 31451708 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Waist circumference ( 26785701)	Age at first birth ( 27798627) Body mass index ( 29273807) Schizophrenia ( 28991256) Sleep duration (short sleep) ( 30846698)
Interacting Genes		9 interacting genes: AGO3 CST9L ETV5 EXT2 GTF2B HYAL3 LSM4 POU2AF1 SUMO2	2 interacting genes: DAB1 SLC22A2
Entrez ID		6582	8372
HPRD ID		04008	04948
Ensembl ID		ENSG00000112499	ENSG00000186792
Uniprot IDs		O15244	O43820
PDB IDs
Enriched GO Terms of Interacting Partners?
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