SLC6A4 and CALR

Number of citations of the paper that reports this interaction (PubMedID 10364189)
18

Data Source:
HPRD (in vivo)

		SLC6A4	CALR
Description		solute carrier family 6 member 4	calreticulin
Image
GO Annotations	Cellular Component	Plasma Membrane Focal Adhesion Endosome Membrane Endomembrane System Neuron Projection Membrane Raft Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane Serotonergic Synapse	Acrosomal Vesicle Extracellular Region Extracellular Space Cell Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen
	Molecular Function	Serotonin:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Syntaxin-1 Binding Cocaine Binding Identical Protein Binding Metal Ion Binding Nitric-oxide Synthase Binding Actin Filament Binding Serotonin Binding	Complement Component C1q Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Binding Involved In Protein Folding Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding
	Biological Process	Response To Hypoxia Transport Response To Nutrient Memory Circadian Rhythm Response To Toxic Substance Positive Regulation Of Gene Expression Positive Regulation Of Serotonin Secretion Monoamine Transport Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Negative Regulation Of Synaptic Transmission, Dopaminergic Response To Estradiol Social Behavior Neurotransmitter Biosynthetic Process Vasoconstriction Response To Drug Sperm Ejaculation Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Organ Growth Brain Morphogenesis Serotonin Uptake Transmembrane Transport Cellular Response To Retinoic Acid Cellular Response To CGMP Regulation Of Thalamus Size	Negative Regulation Of Transcription By RNA Polymerase II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Receptor-mediated Endocytosis Spermatogenesis Positive Regulation Of Cell Proliferation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum ATF6-mediated Unfolded Protein Response Regulation Of Meiotic Nuclear Division Response To Drug Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Cardiac Muscle Cell Differentiation Negative Regulation Of Cell Cycle Arrest Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Serotonin clearance from the synaptic cleft	ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Fluvoxamine Amphetamine Phentermine Tramadol Citalopram Venlafaxine Atomoxetine Amitriptyline Protriptyline Mirtazapine Loxapine Methylphenidate Pethidine Imipramine Fluoxetine Duloxetine Dextromethorphan Nortriptyline Amoxapine Fenfluramine Mazindol Trazodone Verapamil Paroxetine Trimipramine Minaprine Pseudoephedrine Cocaine Dopamine Sertraline Sibutramine Chlorphenamine Doxepin Nefazodone Desipramine Escitalopram Dexfenfluramine Clomipramine Ephedra MMDA Midomafetamine 4-Methoxyamphetamine Methamphetamine Nomifensine Zimelidine Amineptine Bicifadine Milnacipran OPC-14523 CRx-119 Mianserin Tapentadol Desvenlafaxine Dexmethylphenidate Levomilnacipran Butriptyline Vortioxetine Dosulepin Nisoxetine Tianeptine Dasotraline	Antihemophilic factor, human recombinant Tenecteplase Melatonin Copper Calcium Citrate Calcium Phosphate
Diseases
GWAS		Height ( 28552196)	Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Red blood cell traits ( 23222517)
Interacting Genes		5 interacting genes: CALR CANX STX1A VAMP2 YBX1	46 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB HLA-A HLA-C HLA-E ITGA2B ITGA3 ITGAV LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SIRPA SLC2A1 SLC6A4 SMARCB1 SUMO4 TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF
Entrez ID		6532	811
HPRD ID		01640	00169
Ensembl ID		ENSG00000108576	ENSG00000179218
Uniprot IDs		B2R7Y7 P31645	P27797 V9HW88
PDB IDs		5I6X 5I6Z 5I71 5I73 5I74 5I75 6AWN 6AWO 6AWP 6AWQ 6DZV 6DZW 6DZY 6DZZ	2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY
Enriched GO Terms of Interacting Partners?
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