VPS33A and TNKS

Number of citations of the paper that reports this interaction (PubMedID 11382755)
33

Data Source:
HPRD (in vivo)

		VPS33A	TNKS
Description		VPS33A core subunit of CORVET and HOPS complexes	tankyrase
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GO Annotations	Cellular Component	Cell Lysosomal Membrane Early Endosome Late Endosome Autophagosome AP-3 Adaptor Complex Clathrin-coated Vesicle HOPS Complex Late Endosome Membrane Perinuclear Region Of Cytoplasm Clathrin Complex	Golgi Membrane Pericentriolar Material Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nuclear Pore Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body Nuclear Membrane Mitotic Spindle Pole
	Molecular Function	Protein Binding	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding Histone Binding Protein ADP-ribosylase Activity
	Biological Process	Vesicle Docking Involved In Exocytosis Endosome To Lysosome Transport Protein Transport Vesicle-mediated Transport Platelet Formation Melanosome Localization Lysosome Localization Regulation Of Lysosomal Lumen PH Regulation Of Developmental Pigmentation Autophagosome Maturation	Protein Polyubiquitination Protein ADP-ribosylation Mitotic Spindle Organization Protein Transport Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cellular Response To Nutrient Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Transcription By RNA Polymerase II MRNA Transport Spindle Assembly Cell Division Positive Regulation Of Telomerase Activity Protein Localization To Chromosome, Telomeric Region Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Telomere Capping Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomeric DNA Binding Negative Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion, Telomeric
Pathways			TCF dependent signaling in response to WNT Degradation of AXIN XAV939 inhibits tankyrase, stabilizing AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Bipolar disorder ( 31043756) Bone mineral density (Ward's triangle area) ( 27397699) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) General risk tolerance (MTAG) ( 30643258) Joint mobility (Beighton score) ( 27182965) Metabolite levels ( 22916037) Mosquito bite size ( 28199695) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Regular attendance at a religious group ( 29970889) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Schizophrenia ( 26198764) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Type 2 diabetes ( 30054458)
Interacting Genes		6 interacting genes: MON1A MON1B TNKS VPS11 VPS16 VPS18	19 interacting genes: AXIN1 BABAM1 DISC1 EIF4A1 FANCD2 FNBP1 LNPEP MCL1 NELFE NUMA1 POT1 PTEN SH3BP5 TERF1 TNIK TNKS1BP1 TNKS2 USP25 VPS33A
Entrez ID		65082	8658
HPRD ID		15651	04490
Ensembl ID		ENSG00000139719	ENSG00000173273
Uniprot IDs		Q96AX1	O95271
PDB IDs		4BX8 4BX9	2RF5 3UDD 3UH2 3UH4 4DVI 4I9I 4K4E 4K4F 4KRS 4LI6 4LI7 4LI8 4MSG 4MSK 4MT9 4N3R 4N4V 4OA7 4TOR 4TOS 4U6A 4UUH 4UW1 4W5S 4W6E 5EBT 5ECE 5ETY 5GP7 5JHQ 5JTI 5JU5 5KNI 6QXU
Enriched GO Terms of Interacting Partners?
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