SKP2 and CDH1

Number of citations of the paper that reports this interaction (PubMedID 26474281)
9

Data Source:
BioGRID (enzymatic study)

		SKP2	CDH1
Description		S-phase kinase associated protein 2	cadherin 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex	Extracellular Region Cytoplasm Endosome Trans-Golgi Network Plasma Membrane Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Lateral Plasma Membrane Catenin Complex Flotillin Complex Lamellipodium Cell Junction Cortical Actin Cytoskeleton Apical Junction Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Calcium Ion Binding Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Ankyrin Binding GTPase Activating Protein Binding Identical Protein Binding Gamma-catenin Binding Cadherin Binding Cell Adhesion Molecule Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Viral Process Protein Deubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination Cellular Response To Cell-matrix Adhesion Positive Regulation Of Protein Polyubiquitination	Cell Morphogenesis Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Synapse Assembly Response To Toxic Substance Regulation Of Gene Expression Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Pituitary Gland Development Negative Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Negative Regulation Of Cell Migration Neuron Projection Development Adherens Junction Organization Entry Of Bacterium Into Host Cell Positive Regulation Of Protein Import Into Nucleus Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Transcription, DNA-templated Cellular Response To Lithium Ion Cellular Response To Indole-3-methanol Protein Localization To Plasma Membrane Cell-cell Adhesion Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission
Pathways		APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Degradation of the extracellular matrix Degradation of the extracellular matrix Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells
Drugs
Diseases			Gastric cancer Penile cancer Nasopharyngeal cancer Breast cancer Hepatocellular carcinoma Thyroid cancer
GWAS		Birth weight ( 31043758) Metabolite levels ( 23823483) Red cell distribution width ( 27863252)	Colorectal cancer ( 19011631) Colorectal cancer or advanced adenoma ( 30510241) Cutaneous malignant melanoma ( 26237428) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Ulcerative colitis ( 19915572)
Interacting Genes		62 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1	53 interacting genes: ACTR3 ANAPC7 ARHGAP32 ARVCF CA9 CASP3 CASP8 CBLL1 CDC42 CSE1L CSNK2A1 CTNNA1 CTNNB1 CTNND1 CTNND2 EGFR ERBIN EZR FER FGFR1 FYN GNA12 GNA13 GSK3B HDAC1 HDAC2 IQGAP1 IRS1 ITGAE ITGB7 JUP KEAP1 MAD2L2 MDM2 MYO6 NDRG1 NEDD9 NFE2L2 PIP5K1C PKD1 PKP4 PPP1CA PSEN1 PTPN14 PTPRF PTPRM RAB8B RRM2 SKP2 STOML2 UCHL3 VCL YES1
Entrez ID		6502	999
HPRD ID		03256	01885
Ensembl ID		ENSG00000145604	ENSG00000039068
Uniprot IDs		A0A024R069 Q13309	A0A0U2ZQU7 B3GN61 P12830 Q9UII7
PDB IDs		1FQV 1FS1 1FS2 1LDK 2ASS 2AST	1O6S 2O72 2OMT 2OMU 2OMV 2OMX 2OMY 2OMZ 3FF7 3FF8 3L6X 3L6Y 4ZT1 4ZTE 6CXY 6OLE 6OLF 6OLG
Enriched GO Terms of Interacting Partners?
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