SKIV2L and EXOSC10

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SKIV2L	EXOSC10
Description		Ski2 like RNA helicase	exosome component 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Ski Complex	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin
	Molecular Function	RNA Binding RNA Helicase Activity ATP Binding	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding
	Biological Process	RNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, 3'-5' Exonucleolytic Nonsense-mediated Decay	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Association of TriC/CCT with target proteins during biosynthesis mRNA decay by 3' to 5' exoribonuclease	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 23577725 20861866) Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood metabolite levels ( 24816252) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Inflammatory bowel disease ( 28067908) Prostate cancer ( 23535732) Ulcerative colitis ( 28067908) vWF levels ( 30586737)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		12 interacting genes: CDK11A CDKL5 EXOSC10 EXOSC4 GALNT13 PMPCA RHOU SNRPB TNRC17 TSSK2 WDR1 XRN1	36 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 MPP6 NOMO1 NOMO2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		6499	5394
HPRD ID		02724	16180
Ensembl ID		ENSG00000204351	ENSG00000171824
Uniprot IDs		A0A1U9X8J1 Q15477	Q01780
PDB IDs			2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R
Enriched GO Terms of Interacting Partners?
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