SGK1 and CAMKK1

Number of citations of the paper that reports this interaction (PubMedID 12628440)
6

Data Source:
HPRD (in vivo)

		SGK1	CAMKK1
Description		serum/glucocorticoid regulated kinase 1	calcium/calmodulin dependent protein kinase kinase 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Nuclear Speck	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Calcium Channel Regulator Activity Protein Binding ATP Binding Potassium Channel Regulator Activity Sodium Channel Regulator Activity Chloride Channel Regulator Activity	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Sodium Ion Transport Apoptotic Process Cellular Response To DNA Damage Stimulus Long-term Memory Regulation Of Blood Pressure Peptidyl-serine Phosphorylation Regulation Of Cell Migration Positive Regulation Of Transporter Activity Ion Transmembrane Transport Intracellular Signal Transduction Regulation Of Cell Proliferation Regulation Of Apoptotic Process Neuron Projection Morphogenesis Regulation Of Catalytic Activity Regulation Of DNA-binding Transcription Factor Activity Regulation Of Gastric Acid Secretion Renal Sodium Ion Absorption	Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity
Pathways		Stimuli-sensing channels Regulation of TP53 Degradation Transcriptional Regulation by MECP2 NGF-stimulated transcription	CaMK IV-mediated phosphorylation of CREB CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs Activation of RAC1 downstream of NMDARs
Drugs		Riboflavin Monophosphate [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Body mass index (smoking years interaction) ( 23192594) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Pelvic organ prolapse ( 26545240) Pelvic organ prolapse (moderate/severe) ( 26545240) Schizophrenia (inflammation and infection response interaction) ( 25781172) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)	Smoking behavior ( 19247474)
Interacting Genes		34 interacting genes: ASPG BRAF CAMKK1 CARHSP1 CDKN1B CREB1 FANCA FOXO3 GADD45G GSK3A GSK3B IKBKG KCNJ1 KPNA2 MAGEA1 MAPK7 MAPKAP1 MLLT3 NDRG1 NEDD4 NEDD4L NEK6 PDK1 PDK2 PDPK1 PIK3CA PIN1 PPP2CA RABAC1 RICTOR SLC1A3 SLC9A3R2 TMEM184C UBC	9 interacting genes: AKT1 APP CALM1 CAMK1 CAMK1D CAMK4 PRKAA1 SGK1 YWHAG
Entrez ID		6446	84254
HPRD ID		04264	13000
Ensembl ID		ENSG00000118515	ENSG00000004660
Uniprot IDs		B7Z325 E9PR89 O00141	J3KPJ3 Q8N5S9
PDB IDs		2R5T 3HDM 3HDN	6CCF 6CD6
Enriched GO Terms of Interacting Partners?
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