DCLRE1C and TP53BP1

Number of citations of the paper that reports this interaction (PubMedID 15574327)
265

Data Source:
HPRD (in vivo)

		DCLRE1C	TP53BP1
Description		DNA cross-link repair 1C	tumor protein p53 binding protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Nuclear Body Site Of Double-strand Break DNA Repair Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity	RNA Polymerase II Activating Transcription Factor Binding P53 Binding Damaged DNA Binding Transcription Coregulator Activity Protein Binding Methylated Histone Binding Telomeric DNA Binding Histone Binding Ubiquitin Modification-dependent Histone Binding
	Biological Process	Adaptive Immune Response Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation B Cell Differentiation Protection From Non-homologous End Joining At Telomere V(D)J Recombination Interstrand Cross-link Repair Nucleic Acid Phosphodiester Bond Hydrolysis	DNA Damage Checkpoint Double-strand Break Repair Via Nonhomologous End Joining Cellular Response To DNA Damage Stimulus Positive Regulation Of Isotype Switching Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Protein Homooligomerization Cellular Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Nonhomologous End-Joining (NHEJ)	SUMOylation of transcription factors Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases		T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS		Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)	Antibody level in response to infection ( 25758998) Cardiometabolic and hematological traits ( 27668658) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Lung cancer in ever smokers ( 28604730) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 27036123)
Interacting Genes		11 interacting genes: ATM ATR BRCA1 CDKN1B DDB1 DDB2 MRE11 NBN PRKDC RAD50 TP53BP1	42 interacting genes: ARAP1 ATM BLM BRCA1 BRCA2 CCNB1 CDK1 CHEK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AX H4-16 H4C14 IFI16 KAT8 KDM1A LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 NUDT16L1 PAXIP1 PCNT RAD18 RAD50 RAD51 RBL1 RBL2 RELA SPAG9 SUMO2 TFDP1 TP53 USP28 VAC14
Entrez ID		64421	7158
HPRD ID		05817	05569
Ensembl ID		ENSG00000152457	ENSG00000067369
Uniprot IDs		B3KMX5 Q96SD1	A6NNK5 Q12888
PDB IDs		3W1B 3W1G 4HTP	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 2MWO 2MWP 3LGF 3LGL 3LH0 4CRI 4RG2 4X34 5ECG 5J26 5KGF 5Z78 5ZCJ 6CO1 6CO2 6IU7 6IUA 6MXX 6MXY 6MXZ 6MY0 6RML 6RMM 6UPT
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?