COP1 and MLF1

Number of citations of the paper that reports this interaction (PubMedID 29296815)
2

Data Source:
BioGRID (affinity chromatography technology, pull down)

		COP1	MLF1
Description		COP1 E3 ubiquitin ligase	myeloid leukemia factor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleoplasm Cytosol Nuclear Speck Cul4A-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Cilium Ciliary Basal Body
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	Response To Ionizing Radiation Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cell Cycle Arrest
Pathways		Autodegradation of the E3 ubiquitin ligase COP1 Neddylation
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Depression ( 29700475) Major depressive disorder ( 27479909) Sporadic neuroblastoma ( 28545128) Systolic blood pressure ( 30224653)
Interacting Genes		19 interacting genes: CCT4 CDKN1B DET1 ETS1 ETS2 JUN JUND MLF1 PTPN1 RB1CC1 SFN SIPA1 SOX2 STK40 TP53 TRIB1 UBE2D1 UBE2D2 YWHAZ	8 interacting genes: CENPU COP1 COPS3 GRIK5 MAGEA11 MEOX2 NRBP1 YWHAZ
Entrez ID		64326	4291
HPRD ID		07455	03239
Ensembl ID		ENSG00000143207	ENSG00000178053
Uniprot IDs		Q8NHY2 X5D7N8 X5DNY7	A0A0S2Z4U8 A0A140VKD2 B2RD48 P58340 Q2TLE4 Q5HYH4
PDB IDs		5HQG 5IGQ	3UAL 3UBW
Enriched GO Terms of Interacting Partners?
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