LIN7B and BAIAP2

Number of citations of the paper that reports this interaction (PubMedID 14596909)
12

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		LIN7B	BAIAP2
Description		lin-7 homolog B, crumbs cell polarity complex component	BAR/IMD domain containing adaptor protein 2
Image
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Ruffle Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Microtubule Plasma Membrane Adherens Junction Actin Cytoskeleton Secretory Granule Filopodium Neuronal Cell Body Dendritic Shaft Neuron Projection Terminus Excitatory Synapse Neuron Projection Branch Point Dendritic Spine Cytoplasm Extracellular Exosome Synaptic Membrane Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding	Transcription Cofactor Binding Protein Binding Protein C-terminus Binding Cytoskeletal Adaptor Activity PDZ Domain Binding Identical Protein Binding Proline-rich Region Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane	Plasma Membrane Organization Axonogenesis Brain Development Insulin Receptor Signaling Pathway Regulation Of Cell Shape Response To Bacterium Dendrite Development Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Protein Localization To Synapse Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Synaptic Plasticity Actin Filament Bundle Assembly Actin Crosslink Formation Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Epidermal Growth Factor Stimulus Cell-cell Adhesion Modification Of Synaptic Structure, Modulating Synaptic Transmission Cellular Response To L-glutamate Regulation Of Modification Of Postsynaptic Actin Cytoskeleton Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS			Adverse response to drug ( 30420678) Feeling tense ( 29500382) General factor of neuroticism ( 30867560) Memory performance ( 24392092) Neurociticism ( 29500382) Neuroticism ( 29255261) Serum uric acid levels in response to allopurinol in gout ( 25676789)
Interacting Genes		11 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4	34 interacting genes: ADGRB1 APP ATN1 C19orf25 CDC42 DAPK1 DIAPH1 EGFR ENAH EPS8 ERG28 ESPN GRB10 KANK1 KDM1A LIN7A LIN7B LIN7C MARK2 NCKIPSD NEDD4 PAK1 PBX2 PRR13 RAC1 RTN4 SF3B4 SHANK1 SHANK2 SRPK2 TP53BP2 WASF1 WASF2 YWHAG
Entrez ID		64130	10458
HPRD ID		10040	05686
Ensembl ID		ENSG00000104863	ENSG00000175866
Uniprot IDs		Q9HAP6	I3L4C2 Q9UQB8
PDB IDs		2DKR	1WDZ 1Y2O 2YKT 3RNJ 4JS0 6BCR 6BCY 6BD1 6BD2 6BQT
Enriched GO Terms of Interacting Partners?
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