NOD2 and HAP1

Number of citations of the paper that reports this interaction (PubMedID 27812135)
3

Data Source:
BioGRID (two hybrid)

		NOD2	HAP1
Description		nucleotide binding oligomerization domain containing 2	huntingtin associated protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Basolateral Plasma Membrane Vesicle Protein-containing Complex	Cell Nucleolus Cytoplasm Mitochondrion Lysosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Dendrite Growth Cone Cytoplasmic Vesicle Dendritic Spine Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding	Signaling Receptor Binding Protein Binding Myosin Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Activation Of MAPK Activity Cytokine Production Involved In Immune Response Cytokine Secretion Involved In Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Defense Response JNK Cascade Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Protein Localization Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Anterograde Axonal Transport Of Mitochondrion Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly
Pathways		NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs
Diseases		Blau syndrome Crohn's disease
GWAS		Asthma ( 31361310 30929738) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464 28067908) Leprosy ( 20018961 27976721 25642632) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)	Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		37 interacting genes: ALPI ANKHD1 ANXA2 C10orf67 CCL13 CHMP4B CHMP5 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP	70 interacting genes: ANTKMT APLP1 ATP5MF BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FEZ1 GADD45G GIT1 GPRASP2 HGS HMOX2 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691
Entrez ID		64127	9001
HPRD ID		05810	02972
Ensembl ID		ENSG00000167207	ENSG00000173805
Uniprot IDs		A0A286YF65 Q9HC29	P54257
PDB IDs
Enriched GO Terms of Interacting Partners?
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