CDH23 and CLK1

Number of citations of the paper that reports this interaction (PubMedID 26167880)
16

Data Source:
BioGRID (enzymatic study)

		CDH23	CLK1
Description		cadherin related 23	CDC like kinase 1
Image
GO Annotations	Cellular Component	Cell Plasma Membrane Adherens Junction Cell Surface Membrane Integral Component Of Membrane Catenin Complex Stereocilium	Nucleus Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Cytoskeletal Protein Binding Cadherin Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Cell Morphogenesis Calcium Ion Transport Cell-cell Junction Assembly Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Multicellular Organism Development Visual Perception Sensory Perception Of Sound Locomotory Behavior Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Cell-cell Adhesion Mediated By Cadherin Photoreceptor Cell Maintenance Response To Stimulus Sensory Perception Of Light Stimulus Equilibrioception Regulation Of Cytosolic Calcium Ion Concentration Inner Ear Receptor Cell Stereocilium Organization Cell-cell Adhesion	Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of RNA Splicing Protein Autophosphorylation
Pathways
Drugs			Debromohymenialdisine ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate
Diseases		Usher syndrome (US) Deafness, autosomal recessive
GWAS		Age at smoking initiation in chronic obstructive pulmonary disease ( 21685187) Bipolar disorder (body mass index interaction) ( 24322204) Blood protein levels ( 29875488) Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Cognitive performance (processing speed) ( 31598132) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diffusing capacity of the lung for carbon monoxide traits ( 30049742) Diisocyanate-induced asthma ( 25918132) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Kidney function decline traits ( 25493955) Monocyte count ( 27863252) Progranulin levels ( 29186428) Selective IgA deficiency ( 27723758) Self-reported risk-taking behaviour ( 30271922) Vitiligo ( 22951725)	Breast cancer ( 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Triptolide cytotoxicity ( 26121980)
Interacting Genes		3 interacting genes: CLK1 MYO7A USH1C	159 interacting genes: ABCA13 ACOX2 ANKFY1 ARHGEF12 ARPC4 ASL ASXL3 ATP10A ATP4A BCLAF1 BCS1L C1orf94 CDCP1 CDH23 CDK12 CELSR3 CENPE CEP95 CFAP20DC CFAP251 CKAP5 CLASRP COCH CRNKL1 CTNND2 CUL3 CWC27 CYP46A1 DBR1 DENND4A DNAJC13 DNAJC24 DPYD DSC2 ECE1 ELP6 ENO1 ERFE FAM160B2 FAM189A1 FAT1 FBF1 GEMIN5 GOLM1 GRM6 GSDMB H2BC12 HADH HIVEP1 HNMT HNRNPA0 HNRNPA1 HNRNPA3 HSP90AB2P HSPBP1 HTATSF1 ICE1 IMPDH2 IP6K1 ITGA5 KATNA1 KHDRBS1 KIF14 KIF23 KRT8 KRTAP10-7 LINS1 LMNA LUC7L3 MAP3K21 MAP7 MBP MFHAS1 MFSD10 MICU3 MKRN2 MTBP MTCL1 MYOM1 NCL NCOR1 NF1 NPM1 NUP153 PATZ1 PDE9A PHF3 PHLDB2 PIAS4 PIP4K2B PKD1L1 PLAAT5 PLXDC2 PPFIBP2 PPHLN1 PPIG PPP1CB PRDX5 PRKDC PRMT5 PRPF38A PRPF4 PRPF4B PTPN1 PTPN22 RAD21L1 RAPH1 RASL12 RBBP6 RBM15 RBM39 RBMX REV1 RLF RPL5 RPS4Y1 RPUSD3 SAFB SAMD9L SCARA3 SERPINI2 SF3B1 SFMBT2 SHROOM1 SLC35D3 SLFN5 SPEN SPTBN4 SRPK1 SRPK2 SRRM1 SRRM2 SRSF1 SRSF3 SRSF5 SRSF6 SRSF7 SSBP3 STIP1 STK31 SVOP TEX11 THRAP3 THY1 TJP2 TLN2 TMPO TMPRSS2 TNIP2 TP53RK TRA2B UBL5 UNC13B VWA7 YTHDC1 YWHAG ZC3H13 ZMYND10 ZNF148
Entrez ID		64072	1195
HPRD ID		05699	09058
Ensembl ID		ENSG00000107736	ENSG00000013441
Uniprot IDs		A0A087WYR8 A5D6V9 Q6P152 Q8N5B3 Q9H251	P49759
PDB IDs		2KBR 2KBS 2LSR 5TFM 5VVM 5WJ8	1Z57 2VAG 5J1V 5J1W 5X8I 6FT8 6FT9 6FYO 6G33 6I5H 6I5I 6I5K 6I5L 6KHD 6Q8K 6Q8P 6RAA
Enriched GO Terms of Interacting Partners?
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