CCL8 and ACKR2

Number of citations of the paper that reports this interaction (PubMedID 9405404)
43

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		CCL8	ACKR2
Description		C-C motif chemokine ligand 8	atypical chemokine receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell	Cell Nucleoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle Recycling Endosome
	Molecular Function	Protein Kinase Activity Protein Binding Chemokine Activity Heparin Binding Phospholipase Activator Activity CCR Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Positive Regulation Of Leukocyte Migration Protein Phosphorylation Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Negative Regulation By Host Of Viral Genome Replication Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Leukocyte Proliferation Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Endocytosis Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Multicellular Organism Development Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways			Chemokine receptors bind chemokines
Drugs		Pidolic Acid
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Crohn's disease ( 22412388)	Blood protein levels ( 29875488 28240269) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Eotaxin levels ( 27989323) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte chemoattractant protein-1 levels ( 27989323) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)
Interacting Genes		9 interacting genes: ACKR1 ACKR2 ACKR4 CCR1 CCR3 CCR5 MMP3 SDF2 VCAN	18 interacting genes: APP CCL11 CCL13 CCL14 CCL19 CCL2 CCL21 CCL25 CCL27 CCL28 CCL3 CCL3L3 CCL4 CCL5 CCL7 CCL8 GPX1 RHOA
Entrez ID		6355	1238
HPRD ID		03791	09095
Ensembl ID		ENSG00000108700	ENSG00000144648
Uniprot IDs		P80075	A1LP82 O00590
PDB IDs		1ESR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?