ATXN1 and UBE2I

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN1	UBE2I
Description		ataxin 1	ubiquitin conjugating enzyme E2 I
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix Nuclear Inclusion Body	Synaptonemal Complex Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol PML Body Transferase Complex Sumoylated E2 Ligase Complex
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Poly(U) RNA Binding Poly(G) Binding Identical Protein Binding Protein Self-association	RNA Binding Protein Binding ATP Binding Transcription Factor Binding SUMO Transferase Activity Enzyme Binding HLH Domain Binding Small Protein Activating Enzyme Binding SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated RNA Processing Nervous System Development Brain Development Learning Memory Social Behavior Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development Nuclear Export	Negative Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Cell Cycle Chromosome Segregation Viral Process Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of SUMO Transferase Activity
Pathways			Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		Amyotrophic lateral sclerosis ( 19451621) Atrial fibrillation ( 30061737 29892015) Breast cancer ( 29059683) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Cortical amyloid beta load ( 29860282) Gambling ( 22780124) General cognitive ability ( 29844566) Generalized epilepsy ( 30531953) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income (MTAG) ( 31844048) Major depressive disorder ( 23377640) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Subcutaneous adipose tissue attenuation (Hounsfield unit scale) ( 27918534) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 28714469) Total body bone mineral density ( 30172743) Visceral adipose tissue attenuation (Hounslow unit scale) ( 27918534) White blood cell count ( 29403010 27863252)	Idiopathic dilated cardiomyopathy ( 29495422) Pulse pressure ( 30224653 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		251 interacting genes: - ACACA ACOT7 ADCY6 ADD3 AHDC1 AKT1 ANKHD1 ANP32A APBB1 ARHGAP32 ARID5A ASNS ATF5 ATP1A3 ATP6V0D1 ATXN1L ATXN2 ATXN2L BAALC BASP1 BATF2 BEND2 BTG3 C1orf94 C2orf27B CAMK2B CCDC136 CCNK CDIP1 CDK6 CFL1 CHRNA7 CIC CIRBP CLASRP CLCN2 CLEC4F COIL CPSF7 CREM CRIP2 CRK CRY2 CST3 DAZAP2 DCTN3 DHRSX DHX37 DIXDC1 DMPK DNAJA3 DOCK5 DZIP3 EFEMP2 EHMT1 EIF1AY EIF1B EIF3F EIF4ENIF1 ELP5 ENTPD6 ESRP1 ESRRA ETV4 FAM193B FAR1 FAT4 FDPS FHL2 FOSL1 FUBP3 FYN GAPDH GATAD1 GCA GCFC2 GGA2 GMEB2 GPATCH8 GSPT1 H2AP H3C1 HEY2 HEYL HIVEP1 HNRNPLL HOTAIR HPCAL1 HSFX1 HSPA1A IGF2R IL34 ILVBL IMMT IPO8 IST1 ITGB4 KAT5 KAT6A KCNAB2 KCTD15 KIAA1549L KIAA2026 KIF22 KLF11 KLHL12 KLHL8 KMT2B LASP1 LDB1 LITAF LOXL1 LPAR2 LRSAM1 MAGEB18 MAGEB2 MAGEB6 MATN2 MBP MED15 METTL17 MLST8 MSMO1 MSX2 MTERF4 MYO18A NARS1 NCAM1 NCOR1 NCOR2 NLK NPHP3 NR4A1 NUDT21 NUMBL NUTM2B OAZ1 OPCML OTX2 PEPD PHPT1 PIAS1 PIM2 PLEKHB1 PML POM121 PPAT PPP6R2 PQBP1 PRDM1 PRR20A PRRC2A PRRC2B PSMC3 PSPH PTGDS PUM1 QKI QRICH1 R3HDM1 R3HDM2 RAD54L2 RAI2 RAPGEF1 RAPGEF4 RBFOX1 RBFOX2 RBM26 RBPMS RCC1L RCN1 REL RHOXF2 RNF31 RNF4 SAR1A SEMA4G SETD2 SF1 SGMS1 SIX5 SLC25A51 SLC4A2 SLC51A SLC6A13 SMARCC2 SPEN SREBF1 SREBF2 ST6GALNAC6 STAC2 STAM2 SUGP2 SUMO1 SUPT20H SV2A SYBU TBC1D5 TBX15 TCAP TCEANC TCTA TDP2 TENT5A TENT5B TMX2 TOLLIP TOMM20 TOX4 TP53I11 TRAF2 TRIM32 TRIM38 TRIP6 TSC1 TTC19 U2AF2 UBAP2L UBE2E3 UBE2I UBQLN4 UHRF1BP1L UHRF2 UNK USP54 USP7 VCP VSNL1 VSTM2L WASHC2C WNK1 WNK2 YWHAE YWHAZ YY1AP1 ZBTB32 ZC3H10 ZC3H7B ZCCHC13 ZHX1 ZHX2 ZHX3 ZNF276 ZNF488 ZNF609 ZNF804A ZSCAN1 ZSWIM8 ZXDC ZYX	376 interacting genes: ADAR ADD3 AGTRAP ANAPC4 ANXA1 APEX1 APP AR ARHGDIA ARL13B ARNT ARNTL ATF2 ATF3 ATF7IP ATXN1 AURKA AURKB BCAM BCL11A BEND5 BHLHE40 BIRC3 BIRC7 BLM BLMH BMI1 C18orf25 CALU CAMSAP2 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CCDC6 CD2AP CDC37 CDCA8 CDH4 CDKN1B CEBPD CEBPE CENPX CFTR CHD3 CHD4 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 COG1 CORO2A CREB1 CREBBP CREM CSNK2B CTBP2 CTNNA1 DACH1 DAXX DDX21 DDX24 DDX39A DDX5 DES DHX9 DNM1 DNMT3A DNMT3B DPYSL2 DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 ELK1 EP300 ESR1 ETS1 ETV1 ETV6 EXO1 EXOSC9 FAF1 FANCM FAS FHIT FHL3 FLI1 FMR1 FOS FOXL2 FOXM1 GCM1 GLUL GMCL1 GMCL2 GMEB1 GMEB2 GOLGA2 GOLGB1 GRIP1 GTF2I H4-16 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIF1A HIPK1 HIPK2 HIPK3 HIRA HMGB1 HMGN2 HNF4A HNRNPC HNRNPD HNRNPK HNRNPLL HNRNPM HNRNPU HSF1 HSF2 HSF2BP IKBKG IKZF1 IKZF3 IKZF5 IPO13 IQGAP1 JUN KAT2A KAT6B KCNA5 KCNK1 KCTD1 KDM1A KHSRP KLF3 KLF5 KLHL12 KMT5A KRT19 LATS1 LMNA LMO2 LNX2 MAP2K1 MAP3K1 MAPK1IP1L MARCHF5 MAT2A MATR3 MDM2 MECOM MED7 MEF2C MGRN1 MITF MKRN3 MRTFA MTA1 MYB MYBBP1A MYH9 NACC1 NAT10 NCOR2 NFKBIA NIN NMI NOL6 NONO NOP2 NOP56 NOP58 NOX5 NR1D2 NR1H2 NR1H3 NR1I2 NR3C1 NR3C2 NR5A1 NR5A2 NSD3 NUDCD3 NVL PARK7 PARP1 PDLIM7 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIM1 PLAAT4 PLAGL1 PML PPARA PPARG PPARGC1A PPM1J PRKAA2 PRKDC PRPF40A PRPF8 PSMC3 PSME3 PTEN PUF60 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RBM14 RBM25 RC3H2 RCBTB2 RFPL3 RHOXF2 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF185 RNF4 RNF40 RORB RPL11 RPL7 RPL8 RPS3A RPS6KA6 RWDD3 RXRA SAE1 SALL1 SART1 SATB1 SCNN1A SEMA6A SETBP1 SETDB1 SETX SFPQ SH3KBP1 SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SLX4 SMAD4 SNAI2 SND1 SNIP1 SNRNP200 SOCS6 SOX10 SOX4 SOX6 SOX9 SP100 SP3 SPECC1L SPOP SREBF1 SREBF2 SRF SSRP1 STAT1 STMN2 SUMO1 SUMO1P1 SUMO2 SUMO3 SUPT7L SUZ12 SYMPK TAB2 TAF1 TAF10 TAF12 TAF5 TBL1X TBL1XR1 TBP TCERG1 TCF3 TCF4 TDG TDP2 TERF2 TFAP2A TFAP2B TFAP2C TFCP2 THRA THRB TNFRSF1A TOP1 TOP2A TOP2B TOPORS TP53 TP63 TP73 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM24 TRIM27 TRIM28 TRIM29 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRIP13 TRPS1 TSHZ2 TSNAX UBA2 UBXN1 UCHL1 UNC119 USP25 VHL WNK1 WT1 WWP2 XBP1 XIAP XRCC1 XRCC5 ZBED1 ZBTB1 ZBTB16 ZBTB26 ZBTB7A ZBTB8A ZCCHC7 ZEB2 ZMYM2 ZNF106 ZNF24 ZNF451 ZNF646 ZNRD1
Entrez ID		6310	7329
HPRD ID		03333	09045
Ensembl ID		ENSG00000124788	ENSG00000103275
Uniprot IDs		P54253 Q96FF1	A8K503 B0QYN7 P63279
PDB IDs		1OA8 2M41 4APT 4AQP 4J2J 4J2L	1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2
Enriched GO Terms of Interacting Partners?
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