SAA1 and SELENOS

Number of citations of the paper that reports this interaction (PubMedID 12031974)
43

Data Source:
HPRD (in vitro, two hybrid)

		SAA1	SELENOS
Description		serum amyloid A1	selenoprotein S
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Cytoplasmic Microtubule High-density Lipoprotein Particle Extracellular Exosome Endocytic Vesicle Lumen	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Plasma Membrane Integral Component Of Endoplasmic Reticulum Membrane Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle Derlin-1-VIMP Complex Derlin-1 Retrotranslocation Complex
	Molecular Function	G Protein-coupled Receptor Binding Heparin Binding Chemoattractant Activity	Protein Binding Antioxidant Activity Enzyme Binding Signaling Receptor Activity ATPase Binding Ubiquitin-specific Protease Binding
	Biological Process	Activation Of MAPK Activity Receptor-mediated Endocytosis Acute-phase Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cytokine-mediated Signaling Pathway Platelet Activation Neutrophil Chemotaxis Cellular Protein Metabolic Process Innate Immune Response Positive Regulation Of Cell Adhesion Macrophage Chemotaxis Lymphocyte Chemotaxis Regulation Of Protein Secretion Positive Regulation Of Cytokine Secretion Positive Regulation Of Interleukin-1 Secretion Negative Regulation Of Inflammatory Response Positive Chemotaxis Cell Chemotaxis	Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Gluconeogenesis ER Overload Response Response To Glucose Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Establishment Of Protein Localization Cell Redox Homeostasis Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Glucose Import Negative Regulation Of Inflammatory Response Negative Regulation Of Nitric-oxide Synthase Biosynthetic Process Response To Redox State Cellular Response To Lipopolysaccharide Regulation Of Nitric Oxide Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Macrophage Apoptotic Process
Pathways		Scavenging by Class B Receptors G alpha (q) signalling events G alpha (i) signalling events Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-4 and Interleukin-13 signaling Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation Amyloid fiber formation	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Human Serum Albumin
Diseases
GWAS		Amyloid A serum levels ( 21124955) Blood protein levels ( 30072576 29875488 28240269) Rosacea symptom severity ( 29771307)
Interacting Genes		10 interacting genes: COL4A1 COL4A2 COL4A3 COL4A4 FPR1 GLP1R GNG5 LAMA1 SELENOS VKORC1	24 interacting genes: BLZF1 CD180 CELF4 DERL1 EIF2AK1 ETV7 GTF2IRD1 KLHDC2 KPNB1 LIMK1 LINS1 LRRK1 MFHAS1 NCBP1 OR4F4 SAA1 SNRPA1 SRPK2 SYNM TARS3 TM2D3 TTC23 VCP ZBTB33
Entrez ID		6288	55829
HPRD ID		00097	12133
Ensembl ID		ENSG00000173432	ENSG00000131871
Uniprot IDs		P0DJI8	Q6GYA4 Q9BQE4
PDB IDs		4IP8 4IP9 6MST	2Q2F 5KIU 5KIY 6DO4
Enriched GO Terms of Interacting Partners?
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