RYK and WNT3A

Number of citations of the paper that reports this interaction (PubMedID 15454084)
146

Data Source:
HPRD (in vitro)

		RYK	WNT3A
Description		receptor like tyrosine kinase	Wnt family member 3A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Wnt-activated Receptor Activity Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Protein Binding Protein Domain Specific Binding Co-receptor Binding Receptor Ligand Activity
	Biological Process	Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Nervous System Development Axonogenesis Axon Guidance Synapse Assembly Wnt Signaling Pathway Peptidyl-tyrosine Phosphorylation Neurogenesis Corpus Callosum Development Neuron Differentiation Neuron Projection Development Cell Proliferation In Midbrain Positive Regulation Of Kinase Activity Non-canonical Wnt Signaling Pathway Chemorepulsion Of Dopaminergic Neuron Axon Positive Regulation Of MAPK Cascade Skeletal System Morphogenesis Negative Regulation Of Axon Extension Involved In Axon Guidance Canonical Wnt Signaling Pathway Commissural Neuron Axon Guidance Planar Cell Polarity Pathway Involved In Axon Guidance Midbrain Dopaminergic Neuron Differentiation Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation	Osteoblast Differentiation In Utero Embryonic Development Positive Regulation Of Cytokine Production Positive Regulation Of Protein Phosphorylation Heart Looping Positive Regulation Of Receptor Internalization Negative Regulation Of Heart Induction By Canonical Wnt Signaling Pathway Axon Guidance Cell Proliferation Positive Regulation Of Cell Proliferation COP9 Signalosome Assembly Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Hemopoiesis Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Protein Binding Positive Regulation Of Peptidyl-serine Phosphorylation Cell Proliferation In Midbrain Cellular Protein Localization Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling Inner Ear Morphogenesis Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Positive Regulation Of DNA-binding Transcription Factor Activity Canonical Wnt Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Dermatome Development Canonical Wnt Signaling Pathway Involved In Cardiac Muscle Cell Fate Commitment Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Postsynapse To Nucleus Signaling Pathway Negative Regulation Of Neuron Death Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Core Promoter Binding Beta-catenin Destruction Complex Disassembly Wnt Signaling Pathway Involved In Midbrain Dopaminergic Neuron Differentiation Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Canonical Wnt Signaling Pathway Involved In Controlling Type B Pancreatic Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways		TCF dependent signaling in response to WNT PCP/CE pathway	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
Drugs
Diseases
GWAS		Cadmium levels ( 26025379) Diastolic blood pressure ( 27841878 30578418) Height ( 31562340) Systolic blood pressure ( 28135244 27841878)	Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		8 interacting genes: EPHB2 EPHB3 FZD8 PPM1B PPP3CA PTPRR WNT1 WNT3A	11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		6259	89780
HPRD ID		02751	05897
Ensembl ID		ENSG00000163785	ENSG00000154342
Uniprot IDs		P34925 Q59FQ5 Q8WTZ8	P56704
PDB IDs
Enriched GO Terms of Interacting Partners?
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