RXRA and PPARA

Number of citations of the paper that reports this interaction (PubMedID 10195690)
8

Data Source:
HPRD (in vitro)

		RXRA	PPARA
Description		retinoid X receptor alpha	peroxisome proliferator activated receptor alpha
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Mitochondrion Protein-containing Complex Receptor Complex RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Retinoic Acid Binding DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Enzyme Binding Chromatin DNA Binding Signaling Receptor Activity Peptide Binding Identical Protein Binding Vitamin D Receptor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoic Acid-responsive Element Binding DBD Domain Binding LBD Domain Binding Vitamin D Response Element Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Fatty Acid Binding Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Nuclear Receptor Transcription Coactivator Activity Ubiquitin Conjugating Enzyme Binding Signaling Receptor Activity Sequence-specific DNA Binding Protein-containing Complex Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Maternal Placenta Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Vitamin Metabolic Process Embryo Implantation Cholesterol Metabolic Process Bile Acid And Bile Salt Transport Modulation By Virus Of Host Morphology Or Physiology Regulation Of Lipid Metabolic Process Cell Differentiation Response To Retinoic Acid Peroxisome Proliferator Activated Receptor Signaling Pathway Camera-type Eye Development Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation By Iron Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Differentiation Cardiac Muscle Cell Proliferation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Regulation Of Branching Involved In Prostate Gland Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Multicellular Organism Development Heart Development Epidermis Development Hormone-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Response To Nutrient Levels Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Response To Lipid Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Negative Regulation Of Inflammatory Response Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Cellular Response To Lipid Negative Regulation Of Neuron Death Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression PPARA activates gene expression Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Endogenous sterols Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors
Drugs		Alpha-Linolenic Acid Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Etodolac Tretinoin Etretinate Bezafibrate Alfacalcidol Phthalic Acid Doconexent Oleic Acid Arachidonic Acid (5BETA)-PREGNANE-3,20-DIONE 2-chloro-5-nitro-N-phenylbenzamide 1-BENZYL-3-(4-METHOXYPHENYLAMINO)-4-PHENYLPYRROLE-2,5-DIONE 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID tributylstannanyl	Alpha-Linolenic Acid Icosapent Troglitazone Valproic Acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Pioglitazone Gemfibrozil Bezafibrate Prasterone N,N-bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic Acid Resveratrol Phthalic Acid Lauric Acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglixane Elafibranor GW-501516 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID Indeglitazar Myristic acid Aleglitazar Clinofibrate Soybean oil Omega-3 fatty acids Myrrh Leukotriene B4 Fenofibric acid
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Blood pressure ( 24954895) Central corneal thickness ( 28171582 22814818 31798171 23493294 29760442 30894546) Corneal structure ( 23291589) Crohn's disease (need for surgery) ( 23665963) Intelligence ( 22449649) Intraocular pressure ( 29617998) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Cholesterol, total ( 24097068) CTACK levels ( 27989323) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Resting-state electroencephalogram vigilance ( 29703947) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		117 interacting genes: ACVR1 ACVR1B ALOX15B ARID5A ARNTL BCL3 BRD8 CASP2 CHD9 CLOCK CNOT1 COPS2 CSNK2B CTCF CTNNB1 CTSL DNMT3L DNTTIP2 EDF1 ESR1 FUS GADD45A GADD45G GATA2 GK GRIP1 GSK3B HDAC3 HDAC4 HMGA1 IGFBP3 ITGB3BP JAZF1 JMJD1C KIF1A KLF5 MAPK1 MAPK3 MAPK7 MECR MED1 MED24 MED25 MPG MYOD1 NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NFKB1 NFKBIB NPAS2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR1I3 NR2E3 NR2F1 NR2F6 NR3C2 NR4A1 NR4A2 NRBF2 NRIP1 NSD1 PARP1 PLK1 PML POU2F1 POU2F2 PPARA PPARD PPARG PPARGC1A PRKD2 PRMT2 PSMC3IP PSMC5 RAD54L2 RARA RARB RARG RELA RNF8 ROBO4 RPS6KA6 SMAD2 SMARCB1 SMARCD3 SMN1 SNW1 SP1 SRC SRF STAT1 TADA3 TAF11 TAF1B TBP TDG THRA THRB TK1 TMPRSS3 TRIM24 TRIP10 TRIP4 UBE2I UBQLN4 VDR ZBTB16 ZNHIT3	46 interacting genes: AIP AKAP13 BCL2 CDC34 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 PAQR3 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 STAC3 TNP1 UBE2I
Entrez ID		6256	5465
HPRD ID		01577	01369
Ensembl ID		ENSG00000186350	ENSG00000186951
Uniprot IDs		A0A5F9ZHH6 F1D8Q5 P19793 Q6P3U7	F1D8S4 Q07869
PDB IDs		1BY4 1DSZ 1FBY 1FM6 1FM9 1G1U 1G5Y 1K74 1MV9 1MVC 1MZN 1R0N 1RDT 1RXR 1XLS 1XV9 1XVP 1YNW 2ACL 2NLL 2P1T 2P1U 2P1V 2ZXZ 2ZY0 3DZU 3DZY 3E00 3E94 3FAL 3FC6 3FUG 3H0A 3KWY 3NSP 3NSQ 3OAP 3OZJ 3PCU 3R29 3R2A 3R5M 3UVV 4CN2 4CN3 4CN5 4CN7 4J5W 4J5X 4K4J 4K6I 4M8E 4M8H 4N5G 4N8R 4NQA 4OC7 4POH 4POJ 4PP3 4PP5 4RFW 4RMC 4RMD 4RME 4ZO1 4ZSH 5EC9 5JI0 5LYQ 5MJ5 5MK4 5MKJ 5MKU 5MMW 5TBP 5UAN 5Z12 5ZQU 6A5Y 6A5Z 6A60 6FBQ 6FBR 6HN6 6JNO 6SJM 6STI	1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK
Enriched GO Terms of Interacting Partners?
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