RIC8A and MAPK8IP3

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RIC8A	MAPK8IP3
Description		RIC8 guanine nucleotide exchange factor A	mitogen-activated protein kinase 8 interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane	Golgi Membrane Cytoplasm Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Body Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	G-protein Alpha-subunit Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	In Utero Embryonic Development Vasculature Development G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Visual Learning Cell Migration Involved In Gastrulation Positive Regulation Of GTPase Activity Cell-cell Adhesion Involved In Gastrulation Basement Membrane Organization	Activation Of JUN Kinase Activity Vesicle-mediated Transport Axon Regeneration Regulation Of JNK Cascade Axon Development Anterograde Axonal Protein Transport
Pathways
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin concentration ( 29403010) Meningioma ( 29762745) Platelet count ( 24026423) Uterine fibroids ( 21460842 31649266)	Intraocular pressure ( 29617998)
Interacting Genes		20 interacting genes: EFEMP1 GNA13 GNAI1 GNAI2 GNAI3 GNAO1 GNAQ GNAS MAPK8IP3 NECAB2 NUTM1 RABAC1 SDCBP TERF1 TUBB2A UBQLN1 UBQLN4 XPO1 ZDHHC17 ZNF585B	23 interacting genes: ARL4D CASP3 KLC1 KLC2 LDLRAP1 MAP2K1 MAP2K4 MAP2K7 MAP3K11 MAP3K5 MAPK10 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9 PTK2 RAD51 RAF1 RIC8A SRC TLR2 TLR4 TLR9
Entrez ID		60626	23162
HPRD ID		12373	12014
Ensembl ID		ENSG00000177963	ENSG00000138834
Uniprot IDs		Q9NPQ8	A0A087WYG2 B7ZMF3 E9PFH7 Q9UPT6
PDB IDs			4PXJ
Enriched GO Terms of Interacting Partners?
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