TRIM27 and PML

Number of citations of the paper that reports this interaction (PubMedID 9570750)
20

Data Source:
HPRD (in vivo, two hybrid)

		TRIM27	PML
Description		tripartite motif containing 27	promyelocytic leukemia
Image		No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytoplasm Endosome Early Endosome Cytosol PML Body Retromer Complex Nuclear Membrane	Nuclear Chromosome, Telomeric Region Heterochromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Matrix PML Body Early Endosome Membrane Extrinsic Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Nucleic Acid Binding DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding SUMO Binding Protein Homodimerization Activity SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Adaptive Immune Response Negative Regulation Of Protein Kinase Activity Spermatogenesis Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Viral Transcription Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Innate Immune Response Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Actin Nucleation Protein K63-linked Ubiquitination Interferon-gamma Secretion Negative Regulation Of Calcium Ion Import Negative Regulation Of Interleukin-2 Secretion Negative Regulation Of Viral Release From Host Cell	Response To Hypoxia Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Protein Import Into Nucleus Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To UV Response To Gamma Radiation Regulation Of Calcium Ion Transport Into Cytosol Fibroblast Migration Viral Process Negative Regulation Of Angiogenesis Myeloid Cell Differentiation Regulation Of Cell Adhesion Negative Regulation Of Cell Growth PML Body Organization Positive Regulation Of Telomere Maintenance Endoplasmic Reticulum Calcium Ion Homeostasis Circadian Regulation Of Gene Expression Response To Cytokine Regulation Of Circadian Rhythm Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Cell Fate Commitment Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Retinoic Acid Receptor Signaling Pathway Negative Regulation Of Interleukin-1 Beta Secretion Maintenance Of Protein Location In Nucleus Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Branching Involved In Mammary Gland Duct Morphogenesis Protein-containing Complex Assembly Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Interleukin-4 Cellular Senescence Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Viral Release From Host Cell Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Double-strand Break Repair Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis	SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Regulation of TP53 Activity through Acetylation Interferon gamma signaling Regulation of RUNX1 Expression and Activity Regulation of PTEN localization HCMV Early Events
Drugs			Arsenic trioxide
Diseases			Acute myeloid leukemia (AML)
GWAS		Alopecia areata ( 25608926) Asthma ( 31619474 29273806) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Childhood and early adolescence aggressive behavior ( 26087016) Daytime sleep phenotypes ( 27126917) Estimated glomerular filtration rate in diabetes ( 31451708) Experiencing mood swings ( 29500382) Feeling miserable ( 29500382) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549) Lung cancer in ever smokers ( 28604730) Neurociticism ( 29500382) Platelet aggregation ( 20526338) Pre-treatment viral load in HIV-1 infection ( 31219150) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Schizophrenia ( 30285260) Social communication problems ( 24047820)	Accelerometer-based physical activity measurement (fraction of time with accelerations >425 milli-gravities) ( 29899525) Birth weight ( 31043758) Height ( 28552196 20881960 25282103) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Myopia (pathological) ( 23049088) Paget's disease ( 21623375) Physical activity (overall physical activity time) ( 30531941)
Interacting Genes		270 interacting genes: ABCA1 ABCF3 ABHD17A AEN AMMECR1 AMOTL2 ARHGEF3 ARHGEF5 ARIH2 ARMC7 ARNT2 ARPIN ATPAF2 ATXN7 AXIN1 BABAM1 BAG1 BAG5 BEGAIN BEX2 BMI1 BMP7 BYSL C1orf109 CCDC102B CCDC198 CCDC87 CCDC92 CCHCR1 CDC20B CDC23 CDK18 CDKL3 CHCHD3 CHD4 CHUK CKS1B CLK2 CPNE2 CSNK2B CSRP2 CWF19L2 DCX DDX6 DGCR6 DMRT3 DNMT1 DTNBP1 EHHADH EID1 EIF3D EIF3E EIF4E EIF4E2 EPC1 FAM110A FAM126A FAM126B FAM193B FAM214A FAM214B FAM83A FANCM FARS2 FBF1 FBXL19 FBXW5 FHL3 FNDC11 FOXB1 FOXC2 FXYD6 GATAD2B GCC2-AS1 GEM GFAP GFI1B GFM2 GLYCTK GNPDA2 GPANK1 GRB2 GTF2F1 HAUS1 HDAC1 HGS HNRNPLL HR IKBKB IKBKE ILF2 ILK INPP5J IQCE IQCN IQUB JOSD1 KANSL1 KAT14 KAT5 KCTD15 KCTD9 KIF1A KIF9 KIFC3 LASP1 LENG1 LGALS14 LINC00526 LINGO1 LMO1 MAD2L2 MAGEA11 MAGED4B MAGEF1 MAPKBP1 MAT2B MBD4 MCM7 MCOLN1 MDM2 MED21 MEMO1 MIA3 MID2 MOS MRPL40 MTMR6 MVP NCK2 NDE1 NEBL NEDD9 NEIL2 NEK6 NELFE NIF3L1 NME7 NOTCH2NLA NR1D2 NTAQ1 NUDT21 OAS1 OTUB2 PIAS1 PIAS2 PIAS3 PIAS4 PIMREG PLEKHN1 PML POLE2 POLR1C POLR3C PPID PPL PPP1R18 PRAM1 PRKAA1 PRPF31 PSMA1 PSMB1 PSMB3 PTPMT1 PTPN23 PUS7L RAB29 RAMAC RB1 RBM23 RBM41 RBX1 RCOR3 REL RHPN1 RIBC1 RNF213 RNF25 RNF6 RXRB SCNM1 SDCBP SH2D4A SIAH1 SIRPA SLC15A3 SMARCB1 SNRPA SNRPB2 SORBS3 SPATA2 SPATC1L SRSF2 STAMBPL1 STK16 STK25 STK26 TBC1D22B TBK1 TCEA2 TCHP TEAD4 TLE5 TMSB4X TMSB4XP6 TP53 TPM3 TPRKB TRAF5 TRIM11 TRIM21 TRIM23 TRIM29 TRIM31 TRIM32 TRIM42 TRIM43 TRIM55 TRIM9 TSGA10IP TSHZ3 TTLL10 TUBGCP4 TUFT1 TXNDC9 UBE2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2J1 UBE2K UBE2L6 UBE2N UBE2O UBE2T UBE2U UBE2W UBE2Z UBL5 UCHL3 UCHL5 UHRF2 USE1 USP2 UTP23 VPS25 VPS28 WT1-AS XPA YJU2 ZBTB16 ZC2HC1C ZFC3H1 ZFYVE21 ZGPAT ZMYND19 ZNF250 ZNF384 ZNF417 ZNF446 ZNF572 ZNF581 ZNF688 ZNF79	109 interacting genes: ADH1B ANKRD2 ARID3A ARNT ATF2 ATXN1 AURKA AXIN1 BANP BCL2 BCL6 CASP8AP2 CCNT1 CDK1 CDK2 CDK6 CHFR CREBBP CSNK2A1 DAXX EGFR EIF4E ELF4 EP300 FOS GATA1 GATA2 HDAC1 HDAC2 HDAC3 HHEX HIPK2 HTT KAT5 KAT6A KLHL20 MAD1L1 MAPK11 MAPK14 MDM2 MED7 MXD1 MYB MYC NACC1 NCOA2 NCOR1 NCOR2 NFKB1 NR3C1 NR4A1 PAWR PAXIP1 PCBD2 PIAS1 PIAS2 PIN1 PLAGL1 PLSCR1 POLR2E PPARG PSMA3 RARA RB1 RBX1 RELA RNF111 RNF125 RPL11 RXRA SENP1 SENP2 SH3GL1 SIAH2 SIN3A SIRT1 SKI SLC27A2 SMAD3 SP1 SP100 SRF STAT3 SUMO1 SUMO2 SUMO3 SUV39H1 SYNE2 TDG TERF2IP TGFBR1 TGFBR2 TGIF1 THRA TOPBP1 TP53 TP63 TP73 TRIB3 TRIM24 TRIM27 TRIM69 UBE2I UBE2U UBE3A USP11 ZBTB16 ZFYVE9 ZNF451
Entrez ID		5987	5371
HPRD ID		15996	00023
Ensembl ID		ENSG00000204713	ENSG00000140464
Uniprot IDs		A0A1U9X8R9 P14373	P29590
PDB IDs			1BOR 2MVW 2MWX 4WJN 4WJO 5YUF 6IMQ 6UYO 6UYP 6UYQ 6UYR 6UYS 6UYT 6UYU 6UYV
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?