RELB and DPF2

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
HPRD (in vitro)

		RELB	DPF2
Description		RELB proto-oncogene, NF-kB subunit	double PHD fingers 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Centrosome Cytosol Transcriptional Repressor Complex Protein-containing Complex I-kappaB/NF-kappaB Complex	Histone Acetyltransferase Complex Nuclear Chromatin Nucleus Nucleoplasm Centrosome Cytosol Intracellular Membrane-bounded Organelle NBAF Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Kinase Binding Identical Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Transcription Corepressor Activity Histone Acetyltransferase Activity Protein Binding Histone Binding Metal Ion Binding H3K9me3 Modified Histone Binding Lysine-acetylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Stimulatory C-type Lectin Receptor Signaling Pathway Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Antigen Processing And Presentation Lymphocyte Differentiation Negative Regulation Of Interferon-beta Production Circadian Regulation Of Gene Expression Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Myeloid Dendritic Cell Differentiation T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Osmotic Stress	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Nervous System Development Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway Negative Regulation Of Myeloid Progenitor Cell Differentiation
Pathways		Dectin-1 mediated noncanonical NF-kB signaling CD209 (DC-SIGN) signaling NIK - noncanonical NF-kB signaling
Drugs
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Carotid intima media thickness (maximum) ( 31801372) Cerebrospinal AB1-42 levels in mild cognitive impairment ( 29274321) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cerebrospinal fluid AB1-42 levels ( 29274321) Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Cerebrospinal fluid t-tau levels ( 29274321) Cerebrospinal fluid t-tau levels in mild cognitive impairment ( 29274321) Hippocampal volume ( 29274321) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)	Acne (severe) ( 24927181) Urate levels ( 31578528)
Interacting Genes		25 interacting genes: BCL7A BUD31 CDK1 CTSL DPF2 EHMT2 EZH2 GSK3B HDAC6 KPNA2 KPNA6 MALT1 MT1M MTAP NFKB1 NFKB2 RELA SIN3A SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCE1 UQCRFS1 USP11	11 interacting genes: FHL2 H3-4 H3C1 H4C1 LDOC1 LNX1 NFKB2 REL RELB UPF2 ZNF212
Entrez ID		5971	5977
HPRD ID		06886	03394
Ensembl ID		ENSG00000104856	ENSG00000133884
Uniprot IDs		D6R992 Q01201	A0A024R582 J3KMZ8 Q92785
PDB IDs			3IUF 5B79 5VDC
Enriched GO Terms of Interacting Partners?
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