RECQL and MARK3

		RECQL	MARK3
Description		RecQ like helicase	microtubule affinity regulating kinase 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane	Cytoplasm Cytosol Plasma Membrane Dendrite Extracellular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Annealing Helicase Activity 3'-5' DNA Helicase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Tau Protein Binding Tau-protein Kinase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Strand Renaturation DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding	MAPK Cascade Microtubule Cytoskeleton Organization Protein Phosphorylation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Binding Negative Regulation Of Hippo Signaling Intracellular Signal Transduction Peptidyl-serine Autophosphorylation
Pathways			RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Blood protein levels ( 30072576)	Autism spectrum disorder or schizophrenia ( 28540026) Blond vs. brown/black hair color ( 30531825) Body mass index ( 26426971) Coronary artery disease ( 29212778) Femoral neck bone mineral density ( 22504420) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Mean corpuscular hemoglobin ( 27863252) Monocyte count ( 29403010 27863252) Optic disc size ( 31809533) Systolic blood pressure ( 30224653 30578418) Type 2 diabetes ( 30297969)
Interacting Genes		6 interacting genes: KPNA2 KPNA4 MARK3 PLEKHA5 RPA1 UBC	35 interacting genes: ANKRD7 ARHGEF2 ASB13 ATP6V0C CDC25C CDC42BPB CHGB CLASP1 CLASP2 CPSF4 DYNLL1 FANCF FBXO7 HDAC7 HMOX2 KSR1 MAP2 MAPT MITF NOL11 PKP2 PMPCB PNPLA2 PRKCQ RCOR3 RECQL SAAL1 SFN SLC27A4 TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		5965	4140
HPRD ID		02762	04058
Ensembl ID		ENSG00000004700	ENSG00000075413
Uniprot IDs		A0A024RAV2 P46063	P27448 Q86U11
PDB IDs		2V1X 2WWY 4U7D	2QNJ 3FE3
Enriched GO Terms of Interacting Partners?
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