RDH5 and ORC4

Number of citations of the paper that reports this interaction (PubMedID 27107012)
28

Data Source:
BioGRID (two hybrid)

		RDH5	ORC4
Description		retinol dehydrogenase 5	origin recognition complex subunit 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Membrane Cell Body	Nuclear Chromosome, Telomeric Region Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytosol
	Molecular Function	Retinol Dehydrogenase Activity Protein Homodimerization Activity Androsterone Dehydrogenase Activity Androstan-3-alpha,17-beta-diol Dehydrogenase Activity	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Retinoid Metabolic Process Visual Perception Steroid Metabolic Process Retinol Metabolic Process Response To Stimulus Oxidation-reduction Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs		NADH Vitamin A
Diseases		Familial flecked retina syndrome, including: Doyne honeycomb degeneration of retina (DHRD); Basal laminar drusen (BLD); Fundus albipunctatus (FA); Retinitis punctata albescens (RPA); Bietti crystalline corneoretinal dystrophy (BCD)	Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Advanced age-related macular degeneration ( 26691988) Macular thickness ( 30535121) Myopia ( 27182965) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Estimated glomerular filtration rate ( 31152163 31015462 30604766) Loneliness (MTAG) ( 29970889) Serum uric acid levels ( 30993211) Urate levels ( 31578528)
Interacting Genes		3 interacting genes: ORC4 RGR RLBP1	28 interacting genes: APP CCND1 CDKN2A CTBP1 FBXL5 FBXL8 FBXO25 FBXO6 H3-4 H4-16 KPNA1 MCM10 MCM2 MCM3 MCM4 MCM6 MCM7 MLH1 MTUS1 ORC1 ORC2 ORC3 ORC5 ORC6 RDH5 RPA2 RRM2B TCF4
Entrez ID		5959	5000
HPRD ID		03370	09118
Ensembl ID		ENSG00000135437	ENSG00000115947
Uniprot IDs		A0A024RB18 Q92781	A8K7H4 O43929 Q96B14
PDB IDs			5UJ7 5UJM
Enriched GO Terms of Interacting Partners?
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