PLEKHA1 and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 14516276)
10

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vitro)

		PLEKHA1	PTPN13
Description		pleckstrin homology domain containing A1	protein tyrosine phosphatase non-receptor type 13
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Luteinization Phosphatidylinositol Biosynthetic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus
Pathways		Synthesis of PIPs at the plasma membrane	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
Drugs		Citric Acid
Diseases
GWAS		Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Birth weight ( 31043758 27680694) Femoral neck bone mineral density ( 29499414) Height ( 31562340 20189936) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 28566273 24509480 30054458 30297969 30718926 28869590)	Eyebrow thickness ( 26926045) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)
Interacting Genes		8 interacting genes: ATE1 CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4	24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		59338	5783
HPRD ID		09686	02602
Ensembl ID		ENSG00000107679	ENSG00000163629
Uniprot IDs		B3KQL5 Q5RGS4 Q9HB21	Q12923
PDB IDs		1EAZ	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ
Enriched GO Terms of Interacting Partners?
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