RABGGTB and B4GALT7

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RABGGTB	B4GALT7
Description		Rab geranylgeranyltransferase subunit beta	beta-1,4-galactosyltransferase 7
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Rab-protein Geranylgeranyltransferase Complex	Golgi Membrane Golgi Apparatus Integral Component Of Membrane Golgi Cisterna Membrane
	Molecular Function	Rab Geranylgeranyltransferase Activity Protein Binding Zinc Ion Binding Rab GTPase Binding	Beta-N-acetylglucosaminylglycopeptide Beta-1,4-galactosyltransferase Activity Protein Binding Galactosyltransferase Activity Manganese Ion Binding Xylosylprotein 4-beta-galactosyltransferase Activity
	Biological Process	Cellular Protein Modification Process Visual Perception Protein Prenylation Protein Geranylgeranylation Regulation Of Apoptotic Process Post-translational Protein Modification	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Cellular Protein Modification Process Protein N-linked Glycosylation Glycosaminoglycan Metabolic Process Negative Regulation Of Fibroblast Proliferation Supramolecular Fiber Organization
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation	A tetrasaccharide linker sequence is required for GAG synthesis Defective B4GALT7 causes EDS, progeroid type
Drugs		N-Formylmethionine FARNESYL DIPHOSPHATE Geranylgeranyl diphosphate
Diseases			Ehlers-Danlos syndrome (EDS), including: EDS classical type (EDS1/2); EDS hypermobility type (EDS3); EDS vascular type (EDS4); EDS kyphoscoliosis type (EDS6); EDS arthrochalasia type (EDS7A/7B); EDS dermatospraxis type (EDS7C); EDS autosomal recessive cardiac valvular form (EDSCV); EDS musculocontractural type (EDSMC); EDS progeroid form (EDSP); Tenascin-X deficiency (TNXD); Brittle cornea syndrome (EDS6B); EDS-like spondylocheiro dysplasia (SCD-EDS) Ehlers-Danlos syndrome, progeroid form
GWAS		Daytime sleep phenotypes ( 27126917) Serum metabolite levels ( 23093944)	Blood protein levels ( 30072576) Methadone dose in opioid dependence ( 28115739) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: ALAS2 ARAF B4GALT7 CHML PTP4A2 RAB11A RAB1A RAB27A RAB37 RAB3A RAB5A RAB6A RAB7A TAFA1 TMEM25 WDR4	3 interacting genes: KRTAP10-3 KRTAP10-7 RABGGTB
Entrez ID		5876	11285
HPRD ID		01532	05060
Ensembl ID		ENSG00000137955	ENSG00000027847
Uniprot IDs		A8KAJ2 P53611 Q6IB63	B3KMT1 Q9UBV7
PDB IDs		6O60	4IRP 4IRQ
Enriched GO Terms of Interacting Partners?
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